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Title: Large cell neuroendocrine - Adenocarcinona mixed tumour of colon: Collision tumour with peculiar behaviour. What do we know about these tumours?
Issue Date: Dec-2015
Citation: Ann Med Surg (Lond).2015 Dec;(4)4:399-403
Abstract: Mixed glandular-endocrine carcinomas are rare tumours of gastrointestinal tract (MANEC). They are more frequent in stomach and hardly one hundred cases have been described in colon. According to Lewis, they are classified into collision (side by side pattern), composite (intermingled) or amphicrine (neuroendocrine and glandular features inside a same cell). Collision tumours are related to biclonal theory: two simultaneous cancerogenic events. Conversely, multidirectional differentiation from a stem cell is accepted as origin of composite tumours. The aim of this paper is to analyse the behaviour of these tumours, with an especial concern about how these tumours metastasise, and the different theories about carcinogenesis.
PMID: 26635955
Rights: openAccess
ISSN: 2049-0801
Appears in Collections:Fundaciones e Institutos de Investigación > FIB H. U. Príncipe de Asturias > Artículos

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