Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12530/19964
Title: | Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis. | |
Authors: | ||
Mesh: | ||
Issue Date: | 2015 | |
Citation: | J Immunol Res.2015;(2015):101879 | |
Abstract: | Psoriasis is a chronic skin disease in which genetics play a major role. Although many genome-wide association studies have been performed in psoriasis, knowledge of the age at onset remains limited. Therefore, we analyzed 173 single-nucleotide polymorphisms in genes associated with psoriasis and other autoimmune diseases in patients with moderate-to-severe plaque psoriasis type I (early-onset, <40 years) or type II (late-onset, ≥40 years) and healthy controls. Moreover, we performed a comparison between patients with type I psoriasis and patients with type II psoriasis. Our comparison of a stratified population with type I psoriasis (n = 155) and healthy controls (N = 197) is the first to reveal a relationship between the CLMN, FBXL19, CCL4L, C17orf51, TYK2, IL13, SLC22A4, CDKAL1, and HLA-B/MICA genes. When we compared type I psoriasis with type II psoriasis (N = 36), we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1. Moreover, we replicated the association between rs12191877 (HLA-C) and type I psoriasis and between type I and type II psoriasis. Our findings highlight the role of genetics in age of onset of psoriasis. | |
PMID: | 26613086 | |
URI: | https://hdl.handle.net/20.500.12530/19964 | |
Rights: | openAccess | |
Appears in Collections: | Hospitales > H. U. Fundación Alcorcón > Artículos Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos Hospitales > H. U. Infanta Leonor > Artículos Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos | |
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