Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20100
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dc.contributor.authorJohansson, Emily M
dc.contributor.authorGarcía-Gutiérrez, María S
dc.contributor.authorMoscoso-Castro, María
dc.contributor.authorManzanares, Jorge
dc.contributor.authorValverde, Olga
dc.date.accessioned2019-06-28T12:48:42Z-
dc.date.available2019-06-28T12:48:42Z-
dc.date.issued2015
dc.identifier.citationPLoS ONE.2015;(10)11:e0142978
dc.identifier.urihttps://hdl.handle.net/20.500.12530/20100-
dc.description.abstractThe recreational drugs, alcohol and 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") have both been shown to cause immune activation in vivo, and they are linked to cognitive impairment and anxiety-like behaviors in rodents. The neuronal effects of these drugs in the hippocampal area, an area that has been a focus of studies aiming to explain the mechanisms underlying anxiety related-disorders, remains poorly understood. Therefore we investigated the specific inflammatory impact of alcohol and MDMA on this area of the brain and on a hippocampal-related behavioral task. We centered our study on two inflammatory factors linked to anxiety-related disorders, namely Interleukin-1β (IL-1β) and brain-derived neurotrophic factor (BDNF). We subjected drug-consuming mice to a battery of behavioral tests to evaluate general activity, anxiety-like and depressive-live behaviors. We then introduced them to a contextual fear discrimination task and immune-related effects were examined by immunohistochemical and biochemical studies. Our results suggest that there is a relationship between the induction of immune activated pathways by voluntary alcohol consumption and a high-dose MDMA. Furthermore, the ability of mice to perform a contextual fear discrimination task was impaired by drug consumption and we report long term inflammatory alterations in the hippocampus even several weeks after drug intake. This information will be helpful for discovering new selective drug targets, and to develop treatments and preventive approaches for patients with anxiety-related disorders.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAnimals
dc.subject.meshAnxiety
dc.subject.meshBehavior, Animal
dc.subject.meshBrain-Derived Neurotrophic Factor
dc.subject.meshCognition
dc.subject.meshDiscrimination Learning
dc.subject.meshFear
dc.subject.meshGene Expression Profiling
dc.subject.meshGene Expression Regulation
dc.subject.meshHallucinogens
dc.subject.meshHippocampus
dc.subject.meshImmunohistochemistry
dc.subject.meshInflammation
dc.subject.meshInterleukin-1beta
dc.subject.meshMale
dc.subject.meshMaze Learning
dc.subject.meshMice
dc.subject.meshMotor Activity
dc.subject.meshN-Methyl-3,4-methylenedioxyamphetamine
dc.subject.meshNeurons
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshStreet Drugs
dc.subject.meshAlcohol Drinking
dc.titleReduced Contextual Discrimination following Alcohol Consumption or MDMA Administration in Mice.
dc.typeArtículo
dc.identifier.pubmedID26566284
dc.format.volume10
dc.format.pagee0142978
dc.identifier.e-issn1932-6203
dc.identifier.journalPloS one
dc.identifier.doi10.1371/journal.pone.0142978
dc.format.number11
dc.identifier.pmcPMC4643963
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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