Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20134
Title: Esophageal Cicatricial Pemphigoid as an Isolated Involvement Treated with Mycophenolate Mofetil.
Authors: 
Issue Date: 2015
Citation: Case Rep Gastrointest Med.2015;(2015):620374
Abstract: Cicatricial pemphigoid (CP) is a rare blistering autoimmune disease. Esophageal involvement occurs in widespread disease and rarely appears as the only affected organ. We report a 67-year-old Caucasian female with esophageal dysphagia and weight loss. Several oral panendoscopies showed multiple exudative ulcerations with fibrin and webs in mid- and proximal esophagus and a peeling mucosa. There were no lesions in other organs. We established the diagnosis performing a direct immunofluorescence (DIF), demonstrating IgG3 and complement deposition along the basement membrane. As initial treatment the patient received prednisone 60 mg and 1 gr twice daily of mycophenolate mofetil (MMF) as a steroid-sparing agent due to its lower toxicity and its selective mechanism of action. Six months later there was a significant clinical improvement and the esophageal ulcerations had disappeared, developing cicatricial fibrous rings, although no stenosis was present. Four years later, the patient remains asymptomatic with a low maintenance dose of MMF.
PMID: 26557393
URI: https://hdl.handle.net/20.500.12530/20134
Rights: openAccess
ISSN: 2090-6528
Appears in Collections:Hospitales > H. U. Infanta Cristina > Artículos

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