Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20509
Title: Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100.
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Issue Date: 2015
Citation: Mediators Inflamm..2015;(2015):942517
Abstract: We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required.
PMID: 26441484
URI: https://hdl.handle.net/20.500.12530/20509
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos
Hospitales > H. U. La Paz > Artículos

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