Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20647
Title: Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres.
Authors: 
Keywords: 
Mesh: 
Issue Date: 16-Sep-2015
Citation: Mar Drugs.2015 Sep;(13)9:5901-19
Abstract: A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5.
PMID: 26389926
URI: https://hdl.handle.net/20.500.12530/20647
Rights: openAccess
Appears in Collections:Hospitales > H. U. Severo Ochoa > Artículos

Files in This Item:
File Description SizeFormat 
PMC4584360.pdf1.28 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.