Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20754

Title:	Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients.
Authors:	Tornero-Esteban, Pilar Peralta-Sastre, Ascensión Herranz, Eva Rodríguez-Rodríguez, Luis Mucientes, Arkaitz Abásolo, Lydia Marco, Fernando Fernández-Gutiérrez, Benjamín Lamas, José Ramón View more
Mesh:	Aged Aged, 80 and over Antigens, CD Bone Marrow Calcium Cell Lineage Cells, Cultured Chondrogenesis Down-Regulation Female Gene Expression Regulation Humans Male Mesenchymal Stem Cells Middle Aged Osteoarthritis Phosphorylation Protein Kinases Protein Processing, Post-Translational Real-Time Polymerase Chain Reaction Receptors, Cell Surface Transcription Factors Wnt Proteins beta Catenin Osteogenesis Wnt Signaling Pathway View more
Issue Date:	2015
Citation:	PLoS ONE.2015;(10)9:e0137170
Abstract:	Osteoarthritis (OA) is characterized by altered homeostasis of joint cartilage and bone, whose functional properties rely on chondrocytes and osteoblasts, belonging to mesenchymal stem cells (MSCs). WNT signaling acts as a hub integrating and crosstalking with other signaling pathways leading to the regulation of MSC functions. The aim of this study was to evaluate the existence of a differential signaling between Healthy and OA-MSCs during osteogenesis.
PMID:	26352263
URI:	https://hdl.handle.net/20.500.12530/20754
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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