Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20790
Title: Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature.
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Issue Date: 5-Sep-2015
Citation: BMC Genomics.2015 Sep;(16):683
Abstract: The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromised. Functional genomic approaches provide a unique opportunity to globally characterize these adaptive mechanisms. To provide a global perspective on these CWI regulatory mechanisms, we developed chemical-genomic profiling of haploid mutant budding yeast cells to systematically identify in parallel those genes required to cope with stresses interfering the cell wall by different modes of action: β-1,3 glucanase and chitinase activities (zymolyase), inhibition of β-1,3 glucan synthase (caspofungin) and binding to chitin (Congo red).
PMID: 26341223
URI: https://hdl.handle.net/20.500.12530/20790
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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