Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/20866
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dc.contributor.authorLópez-Rubio, Montserrat
dc.contributor.authorGarcia-Marco, Jose Antonio
dc.date.accessioned2019-06-28T13:05:59Z-
dc.date.available2019-06-28T13:05:59Z-
dc.date.issued2015
dc.identifier.citationOnco Targets Ther.2015;(8):2147-56
dc.identifier.issn1178-6930
dc.identifier.urihttps://hdl.handle.net/20.500.12530/20866-
dc.description.abstractHairy cell leukemia (HCL) is a lymphoproliferative B-cell disorder characterized by pancytopenia, splenomegaly, and characteristic cytoplasmic hairy projections. Precise diagnosis is essential in order to differentiate classic forms from HCL variants, such as the HCL-variant and VH4-34 molecular variant, which are more resistant to available treatments. The current standard of care is treatment with purine analogs (PAs), such as cladribine or pentostatin, which provide a high rate of long-lasting clinical remissions. Nevertheless, ~30%-40% of the patients relapse, and moreover, some of these are difficult-to-treat refractory cases. The use of the monoclonal antibody rituximab in combination with PA appears to produce even higher responses, and it is often employed to minimize or eliminate residual disease. Currently, research in the field of HCL is focused on identifying novel therapeutic targets and potential agents that are safe and can universally cure the disease. The discovery of the BRAF mutation and progress in understanding the biology of the disease has enabled the scientific community to explore new therapeutic targets. Ongoing clinical trials are assessing various treatment strategies such as the combination of PA and anti-CD20 monoclonal antibodies, recombinant immunotoxins targeting CD22, BRAF inhibitors, and B-cell receptor signal inhibitors.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjecthairy cell leukemia
dc.subjectibrutinib
dc.subjectimmunotoxins
dc.subjectpurine analogs
dc.subjectrituximab
dc.subjectvemurafenib
dc.titleCurrent and emerging treatment options for hairy cell leukemia.
dc.typeArtículo
dc.identifier.pubmedID26316784
dc.format.volume8
dc.format.page2147-56
dc.identifier.journalOncoTargets and therapy
dc.identifier.doi10.2147/OTT.S70316
dc.identifier.pmcPMC4548752
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Fundaciones e Institutos de Investigación > FIB H. U. Príncipe de Asturias > Artículos

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