Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/22045
Title: An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.
Authors: 
Blein, Sophie
Bardel, Claire
Danjean, Vincent
McGuffog, Lesley
Healey, Sue
Barrowdale, Daniel
Lee, Andrew
Dennis, Joe
Kuchenbaecker, Karoline B
Soucy, Penny
Terry, Mary Beth
Chung, Wendy K
Goldgar, David E
Buys, Saundra S
Janavicius, Ramunas
Tihomirova, Laima
Tung, Nadine
Dorfling, Cecilia M
van Rensburg, Elizabeth J
Neuhausen, Susan L
Ding, Yuan Chun
Gerdes, Anne-Marie
Ejlertsen, Bent
Nielsen, Finn C
Hansen, Thomas Vo
Osorio, Ana
Benitez, Javier
Conejero, Raquel Andrés
Segota, Ena
Weitzel, Jeffrey N
Thelander, Margo
Peterlongo, Paolo
Radice, Paolo
Pensotti, Valeria
Dolcetti, Riccardo
Bonanni, Bernardo
Peissel, Bernard
Zaffaroni, Daniela
Scuvera, Giulietta
Manoukian, Siranoush
Varesco, Liliana
Capone, Gabriele L
Papi, Laura
Ottini, Laura
Yannoukakos, Drakoulis
Konstantopoulou, Irene
Garber, Judy
Hamann, Ute
Donaldson, Alan
Brady, Angela
Brewer, Carole
Foo, Claire
Evans, D Gareth
Frost, Debra
Eccles, Diana
Douglas, Fiona
Cook, Jackie
Adlard, Julian
Barwell, Julian
Walker, Lisa
Izatt, Louise
Side, Lucy E
Kennedy, M John
Tischkowitz, Marc
Rogers, Mark T
Porteous, Mary E
Morrison, Patrick J
Platte, Radka
Eeles, Ros
Davidson, Rosemarie
Hodgson, Shirley
Cole, Trevor
Godwin, Andrew K
Isaacs, Claudine
Claes, Kathleen
De Leeneer, Kim
Meindl, Alfons
Gehrig, Andrea
Wappenschmidt, Barbara
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Plendl, Hansjoerg
Kast, Karin
Rhiem, Kerstin
Ditsch, Nina
Arnold, Norbert
Varon-Mateeva, Raymonda
Schmutzler, Rita K
Preisler-Adams, Sabine
Markov, Nadja Bogdanova
Wang-Gohrke, Shan
de Pauw, Antoine
Lefol, Cédrick
Lasset, Christine
Leroux, Dominique
Rouleau, Etienne
Damiola, Francesca
Dreyfus, Hélène
Barjhoux, Laure
Golmard, Lisa
Uhrhammer, Nancy
Bonadona, Valérie
Sornin, Valérie
Bignon, Yves-Jean
Carter, Jonathan
Van Le, Linda
Piedmonte, Marion
DiSilvestro, Paul A
de la Hoya, Miguel
Caldes, Trinidad
Nevanlinna, Heli
Aittomäki, Kristiina
Jager, Agnes
van den Ouweland, Ans Mw
Kets, Carolien M
Aalfs, Cora M
van Leeuwen, Flora E
Hogervorst, Frans Bl
Meijers-Heijboer, Hanne Ej
Oosterwijk, Jan C
van Roozendaal, Kees Ep
Rookus, Matti A
Devilee, Peter
van der Luijt, Rob B
Olah, Edith
Diez, Orland
Teulé, Alex
Lazaro, Conxi
Blanco, Ignacio
Del Valle, Jesús
Jakubowska, Anna
Sukiennicki, Grzegorz
Gronwald, Jacek
Lubinski, Jan
Durda, Katarzyna
Jaworska-Bieniek, Katarzyna
Agnarsson, Bjarni A
Maugard, Christine
Amadori, Alberto
Montagna, Marco
Teixeira, Manuel R
Spurdle, Amanda B
Foulkes, William
Olswold, Curtis
Lindor, Noralane M
Pankratz, Vernon S
Szabo, Csilla I
Lincoln, Anne
Jacobs, Lauren
Corines, Marina
Robson, Mark
Vijai, Joseph
Berger, Andreas
Fink-Retter, Anneliese
Singer, Christian F
Rappaport, Christine
Kaulich, Daphne Geschwantler
Pfeiler, Georg
Tea, Muy-Kheng
Greene, Mark H
Mai, Phuong L
Rennert, Gad
Imyanitov, Evgeny N
Mulligan, Anna Marie
Glendon, Gord
Andrulis, Irene L
Tchatchou, Sandrine
Toland, Amanda Ewart
Pedersen, Inge Sokilde
Thomassen, Mads
Kruse, Torben A
Jensen, Uffe Birk
Caligo, Maria A
Friedman, Eitan
Zidan, Jamal
Laitman, Yael
Lindblom, Annika
Melin, Beatrice
Arver, Brita
Loman, Niklas
Rosenquist, Richard
Olopade, Olufunmilayo I
Nussbaum, Robert L
Ramus, Susan J
Nathanson, Katherine L
Domchek, Susan M
Rebbeck, Timothy R
Arun, Banu K
Mitchell, Gillian
Karlan, Beth Y
Lester, Jenny
Orsulic, Sandra
Stoppa-Lyonnet, Dominique
Thomas, Gilles
Simard, Jacques
Couch, Fergus J
Offit, Kenneth
Easton, Douglas F
Chenevix-Trench, Georgia
Antoniou, Antonis C
Mazoyer, Sylvie
Phelan, Catherine M
Sinilnikova, Olga M
Cox, David G
Mesh: 
Issue Date: 25-Apr-2015
Citation: Breast Cancer Res..2015 Apr;(17):61
Abstract: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.
PMID: 25925750
URI: https://hdl.handle.net/20.500.12530/22045
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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