Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/22066
Title: Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly.
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Issue Date: 14-Jul-2015
Citation: EMBO J..2015 Jul;(34)14:1859-74
Abstract: Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, comparing between regions prospective of fold and fissure. We find unique transcriptional signatures in each germinal compartment, where thousands of genes are differentially expressed between regions, including ~80% of genes mutated in human cortical malformations. These regional differences emerge from the existence of discrete domains of gene expression, which occur at multiple locations across the developing cortex of ferret and human, but not the lissencephalic mouse. Complex expression patterns emerge late during development and map the eventual location of folds or fissures. Protomaps of gene expression within germinal layers may contribute to define cortical folds or functional areas, but our findings demonstrate that they distinguish the development of gyrencephalic cortices.
PMID: 25916825
URI: https://hdl.handle.net/20.500.12530/22066
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > FIB H. U. Príncipe de Asturias > Artículos

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