Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/22481
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dc.contributor.authorShaw, E
dc.contributor.authorMiró, J M
dc.contributor.authorPuig-Asensio, M
dc.contributor.authorPigrau, C
dc.contributor.authorBarcenilla, F
dc.contributor.authorMurillas, J
dc.contributor.authorGarcia-Pardo, G
dc.contributor.authorEspejo, E
dc.contributor.authorPadilla, B
dc.contributor.authorGarcia-Reyne, A
dc.contributor.authorPasquau, J
dc.contributor.authorRodriguez-Baño, J
dc.contributor.authorLópez-Contreras, J
dc.contributor.authorMontero, M
dc.contributor.authorde la Calle, C
dc.contributor.authorPintado, V
dc.contributor.authorCalbo, E
dc.contributor.authorGasch, O
dc.contributor.authorMontejo, M
dc.contributor.authorSalavert, M
dc.contributor.authorGarcia-Pais, M J
dc.contributor.authorCarratalà, J
dc.contributor.authorPujol, M
dc.date.accessioned2019-06-28T13:39:24Z-
dc.date.available2019-06-28T13:39:24Z-
dc.date.issued2015-03-11
dc.identifier.citationBMJ Open.2015 Mar;(5)3:e006723
dc.identifier.urihttps://hdl.handle.net/20.500.12530/22481-
dc.description.abstractDespite the availability of new antibiotics such as daptomycin, methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia continues to be associated with high clinical failure rates. Combination therapy has been proposed as an alternative to improve outcomes but there is a lack of clinical studies. The study aims to demonstrate that combination of daptomycin plus fosfomycin achieves higher clinical success rates in the treatment of MRSA bacteraemia than daptomycin alone.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectbacteraemia
dc.subjectcombination therapy
dc.subjectdaptomycin
dc.subjectfosfomycin
dc.subjectmethicillin-resistant Staphylococcus aureus (MRSA)
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshBacteremia
dc.subject.meshDaptomycin
dc.subject.meshDrug Combinations
dc.subject.meshFosfomycin
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshResearch Design
dc.subject.meshStaphylococcal Infections
dc.subject.meshTreatment Outcome
dc.subject.meshMethicillin-Resistant Staphylococcus aureus
dc.titleDaptomycin plus fosfomycin versus daptomycin monotherapy in treating MRSA: protocol of a multicentre, randomised, phase III trial.
dc.typeArtículo
dc.identifier.pubmedID25762232
dc.format.volume5
dc.format.pagee006723
dc.identifier.e-issn2044-6055
dc.identifier.journalBMJ open
dc.identifier.doi10.1136/bmjopen-2014-006723
dc.format.number3
dc.identifier.pmcPMC4360784
dc.pubmedtypeClinical Trial, Phase III
dc.pubmedtypeComparative Study
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.pubmedtypeRandomized Controlled Trial
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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