Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/22512
Title: Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Authors: 
Michailidou, Kyriaki
Beesley, Jonathan
Lindstrom, Sara
Canisius, Sander
Dennis, Joe
Lush, Michael J
Maranian, Mel J
Bolla, Manjeet K
Wang, Qin
Shah, Mitul
Perkins, Barbara J
Czene, Kamila
Eriksson, Mikael
Darabi, Hatef
Brand, Judith S
Bojesen, Stig E
Nordestgaard, Børge G
Flyger, Henrik
Nielsen, Sune F
Rahman, Nazneen
Turnbull, Clare
Fletcher, Olivia
Peto, Julian
Gibson, Lorna
dos-Santos-Silva, Isabel
Chang-Claude, Jenny
Flesch-Janys, Dieter
Rudolph, Anja
Eilber, Ursula
Behrens, Sabine
Nevanlinna, Heli
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Khan, Sofia
Aaltonen, Kirsimari
Ahsan, Habibul
Kibriya, Muhammad G
Whittemore, Alice S
John, Esther M
Malone, Kathleen E
Gammon, Marilie D
Santella, Regina M
Ursin, Giske
Makalic, Enes
Schmidt, Daniel F
Casey, Graham
Hunter, David J
Gapstur, Susan M
Gaudet, Mia M
Diver, W Ryan
Haiman, Christopher A
Schumacher, Fredrick
Henderson, Brian E
Le Marchand, Loic
Berg, Christine D
Chanock, Stephen J
Figueroa, Jonine
Hoover, Robert N
Lambrechts, Diether
Neven, Patrick
Wildiers, Hans
van Limbergen, Erik
Schmidt, Marjanka K
Broeks, Annegien
Verhoef, Senno
Cornelissen, Sten
Couch, Fergus J
Olson, Janet E
Hallberg, Emily
Vachon, Celine
Waisfisz, Quinten
Meijers-Heijboer, Hanne
Adank, Muriel A
van der Luijt, Rob B
Li, Jingmei
Liu, Jianjun
Humphreys, Keith
Kang, Daehee
Choi, Ji-Yeob
Park, Sue K
Yoo, Keun-Young
Matsuo, Keitaro
Ito, Hidemi
Iwata, Hiroji
Tajima, Kazuo
Guénel, Pascal
Truong, Thérèse
Mulot, Claire
Sanchez, Marie
Burwinkel, Barbara
Marme, Frederik
Surowy, Harald
Sohn, Christof
Wu, Anna H
Tseng, Chiu-chen
Van Den Berg, David
Stram, Daniel O
González-Neira, Anna
Benitez, Javier
Zamora, M Pilar
Perez, Jose Ignacio Arias
Shu, Xiao-Ou
Lu, Wei
Gao, Yu-Tang
Cai, Hui
Cox, Angela
Cross, Simon S
Reed, Malcolm W R
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Sawyer, Elinor J
Tomlinson, Ian
Kerin, Michael J
Miller, Nicola
Lindblom, Annika
Margolin, Sara
Teo, Soo Hwang
Yip, Cheng Har
Taib, Nur Aishah Mohd
Tan, Gie-Hooi
Hooning, Maartje J
Hollestelle, Antoinette
Martens, John W M
Collée, J Margriet
Blot, William
Signorello, Lisa B
Cai, Qiuyin
Hopper, John L
Southey, Melissa C
Tsimiklis, Helen
Apicella, Carmel
Shen, Chen-Yang
Hsiung, Chia-Ni
Wu, Pei-Ei
Hou, Ming-Feng
Kristensen, Vessela N
Nord, Silje
Alnaes, Grethe I Grenaker
Giles, Graham G
Milne, Roger L
McLean, Catriona
Canzian, Federico
Trichopoulos, Dimitrios
Peeters, Petra
Lund, Eiliv
Sund, Malin
Khaw, Kay-Tee
Gunter, Marc J
Palli, Domenico
Mortensen, Lotte Maxild
Dossus, Laure
Huerta, Jose-Maria
Meindl, Alfons
Schmutzler, Rita K
Sutter, Christian
Yang, Rongxi
Muir, Kenneth
Lophatananon, Artitaya
Stewart-Brown, Sarah
Siriwanarangsan, Pornthep
Hartman, Mikael
Miao, Hui
Chia, Kee Seng
Chan, Ching Wan
Fasching, Peter A
Hein, Alexander
Beckmann, Matthias W
Haeberle, Lothar
Brenner, Hermann
Dieffenbach, Aida Karina
Arndt, Volker
Stegmaier, Christa
Ashworth, Alan
Orr, Nick
Schoemaker, Minouk J
Swerdlow, Anthony J
Brinton, Louise
Garcia-Closas, Montserrat
Zheng, Wei
Halverson, Sandra L
Shrubsole, Martha
Long, Jirong
Goldberg, Mark S
Labrèche, France
Dumont, Martine
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Brauch, Hiltrud
Hamann, Ute
Brüning, Thomas
Radice, Paolo
Peterlongo, Paolo
Manoukian, Siranoush
Bernard, Loris
Bogdanova, Natalia V
Dörk, Thilo
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Devilee, Peter
Tollenaar, Robert A E M
Seynaeve, Caroline
Van Asperen, Christi J
Jakubowska, Anna
Lubinski, Jan
Jaworska, Katarzyna
Huzarski, Tomasz
Sangrajrang, Suleeporn
Gaborieau, Valerie
Brennan, Paul
McKay, James
Slager, Susan
Toland, Amanda E
Ambrosone, Christine B
Yannoukakos, Drakoulis
Kabisch, Maria
Torres, Diana
Neuhausen, Susan L
Anton-Culver, Hoda
Luccarini, Craig
Baynes, Caroline
Ahmed, Shahana
Healey, Catherine S
Tessier, Daniel C
Vincent, Daniel
Bacot, Francois
Pita, Guillermo
Alonso, M Rosario
Álvarez, Nuria
Herrero, Daniel
Simard, Jacques
Pharoah, Paul P D P
Kraft, Peter
Dunning, Alison M
Chenevix-Trench, Georgia
Hall, Per
Easton, Douglas F
Mesh: 
Issue Date: Apr-2015
Citation: Nat. Genet..2015 Apr;(47)4:373-80
Abstract: Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
PMID: 25751625
URI: https://hdl.handle.net/20.500.12530/22512
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos
Hospitales > H. U. La Paz > Artículos

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