Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/22736
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dc.contributor.authorMalgrange, Brigitte
dc.contributor.authorVarela-Nieto, Isabel
dc.contributor.authorde Medina, Philippe
dc.contributor.authorPaillasse, Michael R
dc.date.accessioned2019-06-28T13:43:12Z-
dc.date.available2019-06-28T13:43:12Z-
dc.date.issued2015
dc.identifier.citationFront Aging Neurosci.2015;(7):3
dc.identifier.issn1663-4365
dc.identifier.urihttps://hdl.handle.net/20.500.12530/22736-
dc.description.abstractSensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions. The pathophysiological mechanisms involved in SNHL include oxidative stress, excitotoxicity, inflammation, and ischemia, resulting in synaptic loss, axonal degeneration, and apoptosis of spiral ganglion neurons. The mechanisms associated with SNHL are shared with other neurodegenerative disorders. Cholesterol homeostasis is central to numerous pathologies including neurodegenerative diseases and cholesterol regulates major processes involved in neurons survival and function. The role of cholesterol homeostasis in the physiopathology of inner ear is largely unexplored. In this review, we discuss the findings concerning cholesterol homeostasis in neurodegenerative diseases and whether it should be translated into potential therapeutic strategies for the treatment of SNHL.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectcholesterol homeostasis
dc.subjectexcitotoxicity
dc.subjectliver X receptor
dc.subjectoxysterol
dc.subjectsensorineural hearing loss
dc.titleTargeting cholesterol homeostasis to fight hearing loss: a new perspective.
dc.typeArtículo
dc.identifier.pubmedID25688206
dc.format.volume7
dc.format.page3
dc.identifier.journalFrontiers in aging neuroscience
dc.identifier.doi10.3389/fnagi.2015.00003
dc.identifier.pmcPMC4310297
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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