Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/22794
Title: Genetic studies of body mass index yield new insights for obesity biology.
Authors: 
Locke, Adam E
Kahali, Bratati
Berndt, Sonja I
Justice, Anne E
Pers, Tune H
Day, Felix R
Powell, Corey
Vedantam, Sailaja
Buchkovich, Martin L
Yang, Jian
Croteau-Chonka, Damien C
Esko, Tonu
Fall, Tove
Ferreira, Teresa
Gustafsson, Stefan
Kutalik, Zoltán
Luan, Jian'an
Mägi, Reedik
Randall, Joshua C
Winkler, Thomas W
Wood, Andrew R
Workalemahu, Tsegaselassie
Faul, Jessica D
Smith, Jennifer A
Zhao, Jing Hua
Zhao, Wei
Chen, Jin
Fehrmann, Rudolf
Hedman, Åsa K
Karjalainen, Juha
Schmidt, Ellen M
Absher, Devin
Amin, Najaf
Anderson, Denise
Beekman, Marian
Bolton, Jennifer L
Bragg-Gresham, Jennifer L
Buyske, Steven
Demirkan, Ayse
Deng, Guohong
Ehret, Georg B
Feenstra, Bjarke
Feitosa, Mary F
Fischer, Krista
Goel, Anuj
Gong, Jian
Jackson, Anne U
Kanoni, Stavroula
Kleber, Marcus E
Kristiansson, Kati
Lim, Unhee
Lotay, Vaneet
Mangino, Massimo
Leach, Irene Mateo
Medina-Gomez, Carolina
Medland, Sarah E
Nalls, Michael A
Palmer, Cameron D
Pasko, Dorota
Pechlivanis, Sonali
Peters, Marjolein J
Prokopenko, Inga
Shungin, Dmitry
Stančáková, Alena
Strawbridge, Rona J
Sung, Yun Ju
Tanaka, Toshiko
Teumer, Alexander
Trompet, Stella
van der Laan, Sander W
van Setten, Jessica
Van Vliet-Ostaptchouk, Jana V
Wang, Zhaoming
Yengo, Loïc
Zhang, Weihua
Isaacs, Aaron
Albrecht, Eva
Ärnlöv, Johan
Arscott, Gillian M
Attwood, Antony P
Bandinelli, Stefania
Barrett, Amy
Bas, Isabelita N
Bellis, Claire
Bennett, Amanda J
Berne, Christian
Blagieva, Roza
Blüher, Matthias
Böhringer, Stefan
Bonnycastle, Lori L
Böttcher, Yvonne
Boyd, Heather A
Bruinenberg, Marcel
Caspersen, Ida H
Chen, Yii-Der Ida
Clarke, Robert
Daw, E Warwick
de Craen, Anton J M
Delgado, Graciela
Dimitriou, Maria
Doney, Alex S F
Eklund, Niina
Estrada, Karol
Eury, Elodie
Folkersen, Lasse
Fraser, Ross M
Garcia, Melissa E
Geller, Frank
Giedraitis, Vilmantas
Gigante, Bruna
Go, Alan S
Golay, Alain
Goodall, Alison H
Gordon, Scott D
Gorski, Mathias
Grabe, Hans-Jörgen
Grallert, Harald
Grammer, Tanja B
Gräßler, Jürgen
Grönberg, Henrik
Groves, Christopher J
Gusto, Gaëlle
Haessler, Jeffrey
Hall, Per
Haller, Toomas
Hallmans, Goran
Hartman, Catharina A
Hassinen, Maija
Hayward, Caroline
Heard-Costa, Nancy L
Helmer, Quinta
Hengstenberg, Christian
Holmen, Oddgeir
Hottenga, Jouke-Jan
James, Alan L
Jeff, Janina M
Johansson, Åsa
Jolley, Jennifer
Juliusdottir, Thorhildur
Kinnunen, Leena
Koenig, Wolfgang
Koskenvuo, Markku
Kratzer, Wolfgang
Laitinen, Jaana
Lamina, Claudia
Leander, Karin
Lee, Nanette R
Lichtner, Peter
Lind, Lars
Lindström, Jaana
Lo, Ken Sin
Lobbens, Stéphane
Lorbeer, Roberto
Lu, Yingchang
Mach, François
Magnusson, Patrik K E
Mahajan, Anubha
McArdle, Wendy L
McLachlan, Stela
Menni, Cristina
Merger, Sigrun
Mihailov, Evelin
Milani, Lili
Moayyeri, Alireza
Monda, Keri L
Morken, Mario A
Mulas, Antonella
Müller, Gabriele
Müller-Nurasyid, Martina
Musk, Arthur W
Nagaraja, Ramaiah
Nöthen, Markus M
Nolte, Ilja M
Pilz, Stefan
Rayner, Nigel W
Renstrom, Frida
Rettig, Rainer
Ried, Janina S
Ripke, Stephan
Robertson, Neil R
Rose, Lynda M
Sanna, Serena
Scharnagl, Hubert
Scholtens, Salome
Schumacher, Fredrick R
Scott, William R
Seufferlein, Thomas
Shi, Jianxin
Smith, Albert Vernon
Smolonska, Joanna
Stanton, Alice V
Steinthorsdottir, Valgerdur
Stirrups, Kathleen
Stringham, Heather M
Sundström, Johan
Swertz, Morris A
Swift, Amy J
Syvänen, Ann-Christine
Tan, Sian-Tsung
Tayo, Bamidele O
Thorand, Barbara
Thorleifsson, Gudmar
Tyrer, Jonathan P
Uh, Hae-Won
Vandenput, Liesbeth
Verhulst, Frank C
Vermeulen, Sita H
Verweij, Niek
Vonk, Judith M
Waite, Lindsay L
Warren, Helen R
Waterworth, Dawn
Weedon, Michael N
Wilkens, Lynne R
Willenborg, Christina
Wilsgaard, Tom
Wojczynski, Mary K
Wong, Andrew
Wright, Alan F
Zhang, Qunyuan
Brennan, Eoin P
Choi, Murim
Dastani, Zari
Drong, Alexander W
Eriksson, Per
Franco-Cereceda, Anders
Gådin, Jesper R
Gharavi, Ali G
Goddard, Michael E
Handsaker, Robert E
Huang, Jinyan
Karpe, Fredrik
Kathiresan, Sekar
Keildson, Sarah
Kiryluk, Krzysztof
Kubo, Michiaki
Lee, Jong-Young
Liang, Liming
Lifton, Richard P
Ma, Baoshan
McCarroll, Steven A
McKnight, Amy J
Min, Josine L
Moffatt, Miriam F
Montgomery, Grant W
Murabito, Joanne M
Nicholson, George
Nyholt, Dale R
Okada, Yukinori
Perry, John R B
Dorajoo, Rajkumar
Reinmaa, Eva
Salem, Rany M
Sandholm, Niina
Scott, Robert A
Stolk, Lisette
Takahashi, Atsushi
Tanaka, Toshihiro
van 't Hooft, Ferdinand M
Vinkhuyzen, Anna A E
Westra, Harm-Jan
Zheng, Wei
Zondervan, Krina T
Heath, Andrew C
Arveiler, Dominique
Bakker, Stephan J L
Beilby, John
Bergman, Richard N
Blangero, John
Bovet, Pascal
Campbell, Harry
Caulfield, Mark J
Cesana, Giancarlo
Chakravarti, Aravinda
Chasman, Daniel I
Chines, Peter S
Collins, Francis S
Crawford, Dana C
Cupples, L Adrienne
Cusi, Daniele
Danesh, John
de Faire, Ulf
den Ruijter, Hester M
Dominiczak, Anna F
Erbel, Raimund
Erdmann, Jeanette
Eriksson, Johan G
Farrall, Martin
Felix, Stephan B
Ferrannini, Ele
Ferrières, Jean
Ford, Ian
Forouhi, Nita G
Forrester, Terrence
Franco, Oscar H
Gansevoort, Ron T
Gejman, Pablo V
Gieger, Christian
Gottesman, Omri
Gudnason, Vilmundur
Gyllensten, Ulf
Hall, Alistair S
Harris, Tamara B
Hattersley, Andrew T
Hicks, Andrew A
Hindorff, Lucia A
Hingorani, Aroon D
Hofman, Albert
Homuth, Georg
Hovingh, G Kees
Humphries, Steve E
Hunt, Steven C
Hyppönen, Elina
Illig, Thomas
Jacobs, Kevin B
Jarvelin, Marjo-Riitta
Jöckel, Karl-Heinz
Johansen, Berit
Jousilahti, Pekka
Jukema, J Wouter
Jula, Antti M
Kaprio, Jaakko
Kastelein, John J P
Keinanen-Kiukaanniemi, Sirkka M
Kiemeney, Lambertus A
Knekt, Paul
Kooner, Jaspal S
Kooperberg, Charles
Kovacs, Peter
Kraja, Aldi T
Kumari, Meena
Kuusisto, Johanna
Lakka, Timo A
Langenberg, Claudia
Marchand, Loic Le
Lehtimäki, Terho
Lyssenko, Valeriya
Männistö, Satu
Marette, André
Matise, Tara C
McKenzie, Colin A
McKnight, Barbara
Moll, Frans L
Morris, Andrew D
Morris, Andrew P
Murray, Jeffrey C
Nelis, Mari
Ohlsson, Claes
Oldehinkel, Albertine J
Ong, Ken K
Madden, Pamela A F
Pasterkamp, Gerard
Peden, John F
Peters, Annette
Postma, Dirkje S
Pramstaller, Peter P
Price, Jackie F
Qi, Lu
Raitakari, Olli T
Rankinen, Tuomo
Rao, D C
Rice, Treva K
Ridker, Paul M
Rioux, John D
Ritchie, Marylyn D
Rudan, Igor
Salomaa, Veikko
Samani, Nilesh J
Saramies, Jouko
Sarzynski, Mark A
Schunkert, Heribert
Schwarz, Peter E H
Sever, Peter
Shuldiner, Alan R
Sinisalo, Juha
Stolk, Ronald P
Strauch, Konstantin
Tönjes, Anke
Trégouët, David-Alexandre
Tremblay, Angelo
Tremoli, Elena
Virtamo, Jarmo
Vohl, Marie-Claude
Völker, Uwe
Waeber, Gérard
Willemsen, Gonneke
Witteman, Jacqueline C
Zillikens, M Carola
Adair, Linda S
Amouyel, Philippe
Asselbergs, Folkert W
Assimes, Themistocles L
Bochud, Murielle
Boehm, Bernhard O
Boerwinkle, Eric
Bornstein, Stefan R
Bottinger, Erwin P
Bouchard, Claude
Cauchi, Stéphane
Chambers, John C
Chanock, Stephen J
Cooper, Richard S
de Bakker, Paul I W
Dedoussis, George
Ferrucci, Luigi
Franks, Paul W
Froguel, Philippe
Groop, Leif C
Haiman, Christopher A
Hamsten, Anders
Hui, Jennie
Hunter, David J
Hveem, Kristian
Kaplan, Robert C
Kivimaki, Mika
Kuh, Diana
Laakso, Markku
Liu, Yongmei
Martin, Nicholas G
März, Winfried
Melbye, Mads
Metspalu, Andres
Moebus, Susanne
Munroe, Patricia B
Njølstad, Inger
Oostra, Ben A
Palmer, Colin N A
Pedersen, Nancy L
Perola, Markus
Pérusse, Louis
Peters, Ulrike
Power, Chris
Quertermous, Thomas
Rauramaa, Rainer
Rivadeneira, Fernando
Saaristo, Timo E
Saleheen, Danish
Sattar, Naveed
Schadt, Eric E
Schlessinger, David
Slagboom, P Eline
Snieder, Harold
Spector, Tim D
Thorsteinsdottir, Unnur
Stumvoll, Michael
Tuomilehto, Jaakko
Uitterlinden, André G
Uusitupa, Matti
van der Harst, Pim
Walker, Mark
Wallaschofski, Henri
Wareham, Nicholas J
Watkins, Hugh
Weir, David R
Wichmann, H-Erich
Wilson, James F
Zanen, Pieter
Borecki, Ingrid B
Deloukas, Panos
Fox, Caroline S
Heid, Iris M
O'Connell, Jeffrey R
Strachan, David P
Stefansson, Kari
van Duijn, Cornelia M
Abecasis, Gonçalo R
Franke, Lude
Frayling, Timothy M
McCarthy, Mark I
Visscher, Peter M
Scherag, André
Willer, Cristen J
Boehnke, Michael
Mohlke, Karen L
Lindgren, Cecilia M
Beckmann, Jacques S
Barroso, Inês
North, Kari E
Ingelsson, Erik
Hirschhorn, Joel N
Loos, Ruth J F
Speliotes, Elizabeth K
Mesh: 
Issue Date: 12-Feb-2015
Citation: Nature.2015 Feb;(518)7538:197-206
Abstract: Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
PMID: 25673413
URI: https://hdl.handle.net/20.500.12530/22794
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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