Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23068
Title: Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Authors: 
Kuchenbaecker, Karoline B
Ramus, Susan J
Tyrer, Jonathan
Lee, Andrew
Shen, Howard C
Beesley, Jonathan
Lawrenson, Kate
McGuffog, Lesley
Healey, Sue
Lee, Janet M
Spindler, Tassja J
Lin, Yvonne G
Pejovic, Tanja
Bean, Yukie
Li, Qiyuan
Coetzee, Simon
Hazelett, Dennis
Miron, Alexander
Southey, Melissa
Terry, Mary Beth
Goldgar, David E
Buys, Saundra S
Janavicius, Ramunas
Dorfling, Cecilia M
van Rensburg, Elizabeth J
Neuhausen, Susan L
Ding, Yuan Chun
Hansen, Thomas V O
Jønson, Lars
Gerdes, Anne-Marie
Ejlertsen, Bent
Barrowdale, Daniel
Dennis, Joe
Benitez, Javier
Osorio, Ana
Garcia, Maria Jose
Komenaka, Ian
Weitzel, Jeffrey N
Ganschow, Pamela
Peterlongo, Paolo
Bernard, Loris
Viel, Alessandra
Bonanni, Bernardo
Peissel, Bernard
Manoukian, Siranoush
Radice, Paolo
Papi, Laura
Ottini, Laura
Fostira, Florentia
Konstantopoulou, Irene
Garber, Judy
Frost, Debra
Perkins, Jo
Platte, Radka
Ellis, Steve
Godwin, Andrew K
Schmutzler, Rita Katharina
Meindl, Alfons
Engel, Christoph
Sutter, Christian
Sinilnikova, Olga M
Damiola, Francesca
Mazoyer, Sylvie
Stoppa-Lyonnet, Dominique
Claes, Kathleen
De Leeneer, Kim
Kirk, Judy
Rodriguez, Gustavo C
Piedmonte, Marion
O'Malley, David M
de la Hoya, Miguel
Caldes, Trinidad
Aittomäki, Kristiina
Nevanlinna, Heli
Collée, J Margriet
Rookus, Matti A
Oosterwijk, Jan C
Tihomirova, Laima
Tung, Nadine
Hamann, Ute
Isaccs, Claudine
Tischkowitz, Marc
Imyanitov, Evgeny N
Caligo, Maria A
Campbell, Ian G
Hogervorst, Frans B L
Olah, Edith
Diez, Orland
Blanco, Ignacio
Brunet, Joan
Lazaro, Conxi
Pujana, Miquel Angel
Jakubowska, Anna
Gronwald, Jacek
Lubinski, Jan
Sukiennicki, Grzegorz
Barkardottir, Rosa B
Plante, Marie
Simard, Jacques
Soucy, Penny
Montagna, Marco
Tognazzo, Silvia
Teixeira, Manuel R
Pankratz, Vernon S
Wang, Xianshu
Lindor, Noralane
Szabo, Csilla I
Kauff, Noah
Vijai, Joseph
Aghajanian, Carol A
Pfeiler, Georg
Berger, Andreas
Singer, Christian F
Tea, Muy-Kheng
Phelan, Catherine M
Greene, Mark H
Mai, Phuong L
Rennert, Gad
Mulligan, Anna Marie
Tchatchou, Sandrine
Andrulis, Irene L
Glendon, Gord
Toland, Amanda Ewart
Jensen, Uffe Birk
Kruse, Torben A
Thomassen, Mads
Bojesen, Anders
Zidan, Jamal
Friedman, Eitan
Laitman, Yael
Soller, Maria
Liljegren, Annelie
Arver, Brita
Einbeigi, Zakaria
Stenmark-Askmalm, Marie
Olopade, Olufunmilayo I
Nussbaum, Robert L
Rebbeck, Timothy R
Nathanson, Katherine L
Domchek, Susan M
Lu, Karen H
Karlan, Beth Y
Walsh, Christine
Lester, Jenny
Hein, Alexander
Ekici, Arif B
Beckmann, Matthias W
Fasching, Peter A
Lambrechts, Diether
Van Nieuwenhuysen, Els
Vergote, Ignace
Lambrechts, Sandrina
Dicks, Ed
Doherty, Jennifer A
Wicklund, Kristine G
Rossing, Mary Anne
Rudolph, Anja
Chang-Claude, Jenny
Wang-Gohrke, Shan
Eilber, Ursula
Moysich, Kirsten B
Odunsi, Kunle
Sucheston, Lara
Lele, Shashi
Wilkens, Lynne R
Goodman, Marc T
Thompson, Pamela J
Shvetsov, Yurii B
Runnebaum, Ingo B
Dürst, Matthias
Hillemanns, Peter
Dörk, Thilo
Antonenkova, Natalia
Bogdanova, Natalia
Leminen, Arto
Pelttari, Liisa M
Butzow, Ralf
Modugno, Francesmary
Kelley, Joseph L
Edwards, Robert P
Ness, Roberta B
du Bois, Andreas
Heitz, Florian
Schwaab, Ira
Harter, Philipp
Matsuo, Keitaro
Hosono, Satoyo
Orsulic, Sandra
Jensen, Allan
Kjaer, Susanne Kruger
Hogdall, Estrid
Hasmad, Hanis Nazihah
Azmi, Mat Adenan Noor
Teo, Soo-Hwang
Woo, Yin-Ling
Fridley, Brooke L
Goode, Ellen L
Cunningham, Julie M
Vierkant, Robert A
Bruinsma, Fiona
Giles, Graham G
Liang, Dong
Hildebrandt, Michelle A T
Wu, Xifeng
Levine, Douglas A
Bisogna, Maria
Berchuck, Andrew
Iversen, Edwin S
Schildkraut, Joellen M
Concannon, Patrick
Weber, Rachel Palmieri
Cramer, Daniel W
Terry, Kathryn L
Poole, Elizabeth M
Tworoger, Shelley S
Bandera, Elisa V
Orlow, Irene
Olson, Sara H
Krakstad, Camilla
Salvesen, Helga B
Tangen, Ingvild L
Bjorge, Line
van Altena, Anne M
Aben, Katja K H
Kiemeney, Lambertus A
Massuger, Leon F A G
Kellar, Melissa
Brooks-Wilson, Angela
Kelemen, Linda E
Cook, Linda S
Le, Nhu D
Cybulski, Cezary
Yang, Hannah
Lissowska, Jolanta
Brinton, Louise A
Wentzensen, Nicolas
Hogdall, Claus
Lundvall, Lene
Nedergaard, Lotte
Baker, Helen
Song, Honglin
Eccles, Diana
McNeish, Ian
Paul, James
Carty, Karen
Siddiqui, Nadeem
Glasspool, Rosalind
Whittemore, Alice S
Rothstein, Joseph H
McGuire, Valerie
Sieh, Weiva
Ji, Bu-Tian
Zheng, Wei
Shu, Xiao-Ou
Gao, Yu-Tang
Rosen, Barry
Risch, Harvey A
McLaughlin, John R
Narod, Steven A
Monteiro, Alvaro N
Chen, Ann
Lin, Hui-Yi
Permuth-Wey, Jenny
Sellers, Thomas A
Tsai, Ya-Yu
Chen, Zhihua
Ziogas, Argyrios
Anton-Culver, Hoda
Gentry-Maharaj, Aleksandra
Menon, Usha
Harrington, Patricia
Lee, Alice W
Wu, Anna H
Pearce, Celeste L
Coetzee, Gerry
Pike, Malcolm C
Dansonka-Mieszkowska, Agnieszka
Timorek, Agnieszka
Rzepecka, Iwona K
Kupryjanczyk, Jolanta
Freedman, Matt
Noushmehr, Houtan
Easton, Douglas F
Offit, Kenneth
Couch, Fergus J
Gayther, Simon
Pharoah, Paul P
Antoniou, Antonis C
Chenevix-Trench, Georgia
Mesh: 
Issue Date: Feb-2015
Citation: Nat. Genet..2015 Feb;(47)2:164-71
Abstract: Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.
PMID: 25581431
URI: https://hdl.handle.net/20.500.12530/23068
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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