Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23091
Title: Heteromers of amyloid precursor protein in cerebrospinal fluid.
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Issue Date: 8-Jan-2015
Citation: Mol Neurodegener.2015 Jan;(10):2
Abstract: Soluble fragments of the amyloid precursor protein (APP) generated by α- and β-secretases, sAPPα and sAPPβ, have been postulated as promising new cerebrospinal fluid (CSF) biomarkers for the clinical diagnosis of Alzheimer's disease (AD). However, the capacity of these soluble proteins to assemble has not been explored and could be relevant. Our aim is to characterize possible sAPP oligomers that could contribute to the quantification of sAPPα and sAPPβ in CSF by ELISA, as well as to characterize the possible presence of soluble full-length APP (sAPPf).
PMID: 25573162
URI: https://hdl.handle.net/20.500.12530/23091
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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