Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23093
Title: Comprehensive description of clinical characteristics of a large systemic lupus erythematosus cohort from the Spanish Rheumatology Society Lupus Registry (RELESSER) with emphasis on complete versus incomplete lupus differences.
Authors: 
Filiation: 
[Richi, Patricia] Hosp Infanta Sofia, Dept Rheumatol, Madrid, Spain
[Javier Lopez-Longo, Francisco] Gregorio Maranon Univ Hosp, Dept Rheumatol, Madrid, Spain
[Galindo, Maria; Carreira, Patricia] Doce Octubre Univ Hosp, Dept Rheumatol, Madrid, Spain
[Tomero, Eva] La Princesa Univ Hosp, Dept Rheumatol, Madrid, Spain
[Sanchez-Atrio, Ana] Principe Asturias Univ Hosp, Dept Rheumatol, Madrid, Spain
[Zea, Antonio] Ramon y Cajal Univ Hosp, Dept Rheumatol, Madrid, Spain
[Fernandez de Castro, Monica] Puerta del Hierro Majadahonda Hosp, Dept Rheumatol, Madrid, Spain
[Bonilla, Gema] La Paz Univ Hosp, Dept Rheumatol, Madrid, Spain
Mesh: 
Issue Date: Jan-2015
Citation: Medicine (Baltimore). 2015;(94)1:e267
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement and pronounced racial and ethnic heterogeneity. The aims of the present work were (1) to describe the cumulative clinical characteristics of those patients included in the Spanish Rheumatology Society SLE Registry (RELESSER), focusing on the differences between patients who fulfilled the 1997 ACR-SLE criteria versus those with less than 4 criteria (hereafter designated as incomplete SLE (iSLE)) and (2) to compare SLE patient characteristics with those documented in other multicentric SLE registries.RELESSER is a multicenter hospital-based registry, with a collection of data from a large, representative sample of adult patients with SLE (1997 ACR criteria) seen at Spanish rheumatology departments. The registry includes demographic data, comprehensive descriptions of clinical manifestations, as well as information about disease activity and severity, cumulative damage, comorbidities, treatments and mortality, using variables with highly standardized definitions.A total of 4.024 SLE patients (91% with ≥4 ACR criteria) were included. Ninety percent were women with a mean age at diagnosis of 35.4 years and a median duration of disease of 11.0 years. As expected, most SLE manifestations were more frequent in SLE patients than in iSLE ones and every one of the ACR criteria was also associated with SLE condition; this was particularly true of malar rash, oral ulcers and renal disorder. The analysis-adjusted by gender, age at diagnosis, and disease duration-revealed that higher disease activity, damage and SLE severity index are associated with SLE [OR: 1.14; 95% CI: 1.08-1.20 (P < 0.001); 1.29; 95% CI: 1.15-1.44 (P < 0.001); and 2.10; 95% CI: 1.83-2.42 (P < 0.001), respectively]. These results support the hypothesis that iSLE behaves as a relative stable and mild disease. SLE patients from the RELESSER register do not appear to differ substantially from other Caucasian populations and although activity [median SELENA-SLEDA: 2 (IQ: 0-4)], damage [median SLICC/ACR/DI: 1 (IQ: 0-2)], and severity [median KATZ index: 2 (IQ: 1-3)] scores were low, 1 of every 4 deaths was due to SLE activity.RELESSER represents the largest European SLE registry established to date, providing comprehensive, reliable and updated information on SLE in the southern European population.
PMID: 25569641
URI: https://hdl.handle.net/20.500.12530/23093
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos
Hospitales > H. U. Infanta Sofía > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos
Hospitales > H. U. La Paz > Artículos
Fundaciones e Institutos de Investigación > FIB H. U. Príncipe de Asturias > Artículos
Hospitales > H. U. Ramón y Cajal > Artículos

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