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Title: The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study.
Filiation: [Sánchez-Celaya, Marta] Directora Continuidad Asistencial Hosp Univ Infanta Sofía, Madrid, Spain
Issue Date: May-2015
Citation: J Psychiatry Neurosci. 2015;(40)3:187-96
Abstract: There is limited evidence for a moderating role of both serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk for major depression (MD) developing after childhood maltreatment. However, research on this topic remains inconclusive, and there is a lack of data from longitudinal studies with large and representative population samples. Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.
PMID: 25510949
Rights: openAccess
Appears in Collections:Hospitales > H. U. Infanta Sofía > Artículos
Centros de Atención Primaria > Artículos

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