Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database.

Shi, Qian; de Gramont, Aimery; Grothey, Axel; Zalcberg, John; Chibaudel, Benoist; Schmoll, Hans-Joachim; Seymour, Matthew T; Adams, Richard; Saltz, Leonard; Goldberg, Richard M; Punt, Cornelis J A; Douillard, Jean-Yves; Hoff, Paulo M; Hecht, Joel Randolph; Hurwitz, Herbert; Díaz-Rubio, Eduardo; Porschen, Rainer; Tebbutt, Niall C; Fuchs, Charles; Souglakos, John; Falcone, Alfredo; Tournigand, Christophe; Kabbinavar, Fairooz F; Heinemann, Volker; Van Cutsem, Eric; Bokemeyer, Carsten; Buyse, Marc; Sargent, Daniel J

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23501

Title:	Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database.
Authors:	Shi, Qian de Gramont, Aimery Grothey, Axel Zalcberg, John Chibaudel, Benoist Schmoll, Hans-Joachim Seymour, Matthew T Adams, Richard Saltz, Leonard Goldberg, Richard M Punt, Cornelis J A Douillard, Jean-Yves Hoff, Paulo M Hecht, Joel Randolph Hurwitz, Herbert Díaz-Rubio, Eduardo Porschen, Rainer Tebbutt, Niall C Fuchs, Charles Souglakos, John Falcone, Alfredo Tournigand, Christophe Kabbinavar, Fairooz F Heinemann, Volker Van Cutsem, Eric Bokemeyer, Carsten Buyse, Marc Sargent, Daniel J View more
Mesh:	Adult Aged Aged, 80 and over Angiogenesis Inhibitors Antineoplastic Agents Biomedical Research Colorectal Neoplasms Databases, Factual Digestive System Disease-Free Survival ErbB Receptors Humans Middle Aged Neoplasm Metastasis Neoplasms Outcome Assessment (Health Care) Prognosis Protein Kinase Inhibitors Young Adult Randomized Controlled Trials as Topic View more
Issue Date:	1-Jan-2015
Citation:	J. Clin. Oncol..2015 Jan;(33)1:22-8
Abstract:	Progression-free survival (PFS) has previously been established as a surrogate for overall survival (OS) for first-line metastatic colorectal cancer (mCRC). Because mCRC treatment has advanced in the last decade with extended OS, this surrogacy requires re-examination.
PMID:	25385741
URI:	https://hdl.handle.net/20.500.12530/23501
Rights:	openAccess
Appears in Collections:	Hospitales > H. U. Clínico San Carlos > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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