Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.

Peterlongo, Paolo; Chang-Claude, Jenny; Moysich, Kirsten B; Rudolph, Anja; Schmutzler, Rita K; Simard, Jacques; Soucy, Penny; Eeles, Rosalind A; Easton, Douglas F; Hamann, Ute; Wilkening, Stefan; Chen, Bowang; Rookus, Matti A; Schmidt, Marjanka K; van der Baan, Frederieke H; Spurdle, Amanda B; Walker, Logan C; Lose, Felicity; Maia, Ana-Teresa; Montagna, Marco; Matricardi, Laura; Lubinski, Jan; Jakubowska, Anna; Gómez Garcia, Encarna B; Olopade, Olufunmilayo I; Nussbaum, Robert L; Nathanson, Katherine L; Domchek, Susan M; Rebbeck, Timothy R; Arun, Banu K; Karlan, Beth Y; Orsulic, Sandra; Lester, Jenny; Chung, Wendy K; Miron, Alex; Southey, Melissa C; Goldgar, David E; Buys, Saundra S; Janavicius, Ramunas; Dorfling, Cecilia M; van Rensburg, Elizabeth J; Ding, Yuan Chun; Neuhausen, Susan L; Hansen, Thomas V O; Gerdes, Anne-Marie; Ejlertsen, Bent; Jønson, Lars; Osorio, Ana; Martínez-Bouzas, Cristina; Benitez, Javier; Conway, Edye E; Blazer, Kathleen R; Weitzel, Jeffrey N; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Scuvera, Giulietta; Barile, Monica; Ficarazzi, Filomena; Mariette, Frederique; Fortuzzi, Stefano; Viel, Alessandra; Giannini, Giuseppe; Papi, Laura; Martayan, Aline; Tibiletti, Maria Grazia; Radice, Paolo; Vratimos, Athanassios; Fostira, Florentia; Garber, Judy E; Donaldson, Alan; Brewer, Carole; Foo, Claire; Evans, D Gareth R; Frost, Debra; Eccles, Diana; Brady, Angela; Cook, Jackie; Tischkowitz, Marc; Adlard, Julian; Barwell, Julian; Walker, Lisa; Izatt, Louise; Side, Lucy E; Kennedy, M John; Rogers, Mark T; Porteous, Mary E; Morrison, Patrick J; Platte, Radka; Davidson, Rosemarie; Hodgson, Shirley V; Ellis, Steve; Cole, Trevor; Godwin, Andrew K; Claes, Kathleen; Van Maerken, Tom; Meindl, Alfons; Gehrig, Andrea; Sutter, Christian; Engel, Christoph; Niederacher, Dieter; Steinemann, Doris; Plendl, Hansjoerg; Kast, Karin; Rhiem, Kerstin; Ditsch, Nina; Arnold, Norbert; Varon-Mateeva, Raymonda; Wappenschmidt, Barbara; Wang-Gohrke, Shan; Bressac-de Paillerets, Brigitte; Buecher, Bruno; Delnatte, Capucine; Houdayer, Claude; Stoppa-Lyonnet, Dominique; Damiola, Francesca; Coupier, Isabelle; Barjhoux, Laure; Venat-Bouvet, Laurence; Golmard, Lisa; Boutry-Kryza, Nadia; Sinilnikova, Olga M; Caron, Olivier; Pujol, Pascal; Mazoyer, Sylvie; Belotti, Muriel; Piedmonte, Marion; Friedlander, Michael L; Rodriguez, Gustavo C; Copeland, Larry J; de la Hoya, Miguel; Segura, Pedro Perez; Nevanlinna, Heli; Aittomäki, Kristiina; van Os, Theo A M; Meijers-Heijboer, Hanne E J; van der Hout, Annemarie H; Vreeswijk, Maaike P G; Hoogerbrugge, Nicoline; Ausems, Margreet G E M; van Doorn, Helena C; Collée, J Margriet; Olah, Edith; Diez, Orland; Blanco, Ignacio; Lazaro, Conxi; Brunet, Joan; Feliubadalo, Lidia; Cybulski, Cezary; Gronwald, Jacek; Durda, Katarzyna; Jaworska-Bieniek, Katarzyna; Sukiennicki, Grzegorz; Arason, Adalgeir; Chiquette, Jocelyne; Teixeira, Manuel R; Olswold, Curtis; Couch, Fergus J; Lindor, Noralane M; Wang, Xianshu; Szabo, Csilla I; Offit, Kenneth; Corines, Marina; Jacobs, Lauren; Robson, Mark E; Zhang, Liying; Joseph, Vijai; Berger, Andreas; Singer, Christian F; Rappaport, Christine; Kaulich, Daphne Geschwantler; Pfeiler, Georg; Tea, Muy-Kheng M; Phelan, Catherine M; Greene, Mark H; Mai, Phuong L; Rennert, Gad; Mulligan, Anna Marie; Glendon, Gord; Tchatchou, Sandrine; Andrulis, Irene L; Toland, Amanda Ewart; Bojesen, Anders; Pedersen, Inge Sokilde; Thomassen, Mads; Jensen, Uffe Birk; Laitman, Yael; Rantala, Johanna; von Wachenfeldt, Anna; Ehrencrona, Hans; Askmalm, Marie Stenmark; Borg, Åke; Kuchenbaecker, Karoline B; McGuffog, Lesley; Barrowdale, Daniel; Healey, Sue; Lee, Andrew; Pharoah, Paul D P; Chenevix-Trench, Georgia; Antoniou, Antonis C; Friedman, Eitan

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23544

Title:	Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Authors:	Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B Rudolph, Anja Schmutzler, Rita K Simard, Jacques Soucy, Penny Eeles, Rosalind A Easton, Douglas F Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A Schmidt, Marjanka K van der Baan, Frederieke H Spurdle, Amanda B Walker, Logan C Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B Olopade, Olufunmilayo I Nussbaum, Robert L Nathanson, Katherine L Domchek, Susan M Rebbeck, Timothy R Arun, Banu K Karlan, Beth Y Orsulic, Sandra Lester, Jenny Chung, Wendy K Miron, Alex Southey, Melissa C Goldgar, David E Buys, Saundra S Janavicius, Ramunas Dorfling, Cecilia M van Rensburg, Elizabeth J Ding, Yuan Chun Neuhausen, Susan L Hansen, Thomas V O Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E Blazer, Kathleen R Weitzel, Jeffrey N Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E Donaldson, Alan Brewer, Carole Foo, Claire Evans, D Gareth R Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E Kennedy, M John Rogers, Mark T Porteous, Mary E Morrison, Patrick J Platte, Radka Davidson, Rosemarie Hodgson, Shirley V Ellis, Steve Cole, Trevor Godwin, Andrew K Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L Rodriguez, Gustavo C Copeland, Larry J de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A M Meijers-Heijboer, Hanne E J van der Hout, Annemarie H Vreeswijk, Maaike P G Hoogerbrugge, Nicoline Ausems, Margreet G E M van Doorn, Helena C Collée, J Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R Olswold, Curtis Couch, Fergus J Lindor, Noralane M Wang, Xianshu Szabo, Csilla I Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M Phelan, Catherine M Greene, Mark H Mai, Phuong L Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D P Chenevix-Trench, Georgia Antoniou, Antonis C Friedman, Eitan View more
Mesh:	Adult Breast Neoplasms Cohort Studies Female Genes, BRCA1 Genes, BRCA2 Humans Mutation Ovarian Neoplasms Polymorphism, Single Nucleotide Retrospective Studies Young Adult View more
Issue Date:	Jan-2015
Citation:	Cancer Epidemiol. Biomarkers Prev..2015 Jan;(24)1:308-16
Abstract:	BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.
PMID:	25336561
URI:	https://hdl.handle.net/20.500.12530/23544
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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