Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23810
Title: A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
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Issue Date: Jan-2015
Citation: Gut.2015 Jan;(64)1:111-20
Abstract: Capecitabine is an oral 5-fluorouracil (5-FU) pro-drug commonly used to treat colorectal carcinoma and other tumours. About 35% of patients experience dose-limiting toxicity. The few proven genetic biomarkers of 5-FU toxicity are rare variants and polymorphisms, respectively, at candidate loci dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS).
PMID: 24647007
URI: https://repositoriosaludmadrid.es/handle/20.500.12530/23810
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

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