Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23899
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dc.contributor.authorGonzález-Lama, Yago
dc.contributor.authorGisbert, Javier Pérez
dc.date.accessioned2019-06-28T14:01:24Z-
dc.date.available2019-06-28T14:01:24Z-
dc.date.issued2016-10
dc.identifier.citationFrontline Gastroenterol.2016 Oct;(7)4:301-307
dc.identifier.issn2041-4137
dc.identifier.urihttps://hdl.handle.net/20.500.12530/23899-
dc.description.abstractThiopurines (azathioprine and mercaptopurine) are one of the immunosuppressive mainstays for the treatment of inflammatory bowel disease. In spite of its widespread use, thiopurine metabolism is still not fully understood, and a significant proportion of patients suffer toxicity or lack of efficacy. Different enzymatic pathways with individual variations constitute a pharmacogenetic model that seems to be suitable for monitoring and therapeutic intervention. This review is focused on current concepts and recent research that may help clinicians to rationally optimise thiopurine treatment in patients with inflammatory bowel disease.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject6-MERCAPTOPURINE
dc.subjectAZATHIOPRINE
dc.subjectDRUG METABOLISM
dc.subjectDRUG TOXICITY
dc.subjectIBD CLINICAL
dc.titleMonitoring thiopurine metabolites in inflammatory bowel disease.
dc.typeArtículo
dc.identifier.pubmedID28839871
dc.format.volume7
dc.format.page301-307
dc.identifier.journalFrontline gastroenterology
dc.identifier.doi10.1136/flgastro-2015-100681
dc.format.number4
dc.identifier.pmcPMC5369498
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Hospitales > H. U. Puerta de Hierro Majadahonda > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Puerta de Hierro-Segovia de Arana > Artículos

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