Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/24440
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dc.contributor.authorPérez-Cabezas, Begoña-
dc.contributor.authorCecílio, Pedro-
dc.contributor.authorRobalo, Ana Luisa-
dc.contributor.authorSilvestre, Ricardo-
dc.contributor.authorCarrillo, Eugenia-
dc.contributor.authorMoreno, Javier-
dc.contributor.authorSan Martin, Juan Victor-
dc.contributor.authorVasconcellos, Rita-
dc.contributor.authorCordeiro-da-Silva, Anabela-
dc.date.accessioned2019-06-28T14:12:44Z-
dc.date.available2019-06-28T14:12:44Z-
dc.date.issued2016-
dc.identifier.citationFront Immunol.2016;(7):478-
dc.identifier.issn1664-3224-
dc.identifier.urihttps://hdl.handle.net/20.500.12530/24440-
dc.description.abstractThe complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BL/6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens. Neutralization of IL-27 in acutely infected BALB/c led to decreased parasite burdens and a transient increase in IFN-γ+ splenic T cells, while administration of IL-27 to C57BL/6 promoted a local anti-inflammatory cytokine response at the site of infection and increased parasite loads. Overall, we show that, as in humans, BALB/c IL-27 systemic levels are infection dependently upregulated and may favor parasite installation by controlling inflammation.-
dc.language.isoeng-
dc.rightsopenAccess-
dc.subjectIL-27-
dc.subjectLeishmania infantum-
dc.subjecthuman-
dc.subjectimmune regulation-
dc.subjectmouse models-
dc.subject.meshLeishmania infantum-
dc.subject.meshInterleukin-27-
dc.subject.meshMice-
dc.titleInterleukin-27 early impacts Leishmania infantum infection in mice and correlates with active visceral disease in humans.-
dc.typeArtículo-
dc.identifier.pubmedID27867384-
dc.format.volume7-
dc.format.page478-
dc.identifier.journalFrontiers in immunology-
dc.identifier.doi10.3389/fimmu.2016.00478-
dc.subject.decsLeishmania infantum-
dc.subject.decsInterleucina-27-
dc.subject.decsRatones-
dc.identifier.pmcPMC5095612-
dc.pubmedtypeJournal Article-
Appears in Collections:Hospitales > H. U. de Fuenlabrada > Artículos

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