A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/25046

Title:	A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.
Authors:	Torices, Silvia Julia, Antonio Muñoz, Pedro Varela, Ignacio Balsa, Alejandro Marsal, Sara Fernández-Nebro, Antonio Blanco, Francisco López-Hoyos, Marcos Martinez-Taboada, Víctor Fernández-Luna, Jose L View more
Keywords:	Infliximab NFkB Rheumatoid arthritis TLR10 variant View more
Mesh:	Aged Antirheumatic Agents Arthritis, Rheumatoid Drug Resistance Female Gene Expression Regulation Genotype High-Throughput Nucleotide Sequencing Humans Infliximab Male Middle Aged NF-kappa B Polymorphism, Single Nucleotide Prognosis Real-Time Polymerase Chain Reaction Toll-Like Receptor 10 View more
Issue Date:	2016
Citation:	Arthritis Res. Ther..2016 10;(18)1:221
Abstract:	Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unknown. We aimed at identifying TLR10 variants within all coding regions of the gene in patients with RA as well as studying their functional and clinical significance.
PMID:	27716427
URI:	https://hdl.handle.net/20.500.12530/25046
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Hospitales > H. U. La Paz > Artículos

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