Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/25113
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBustos-Morán, Eugenio
dc.contributor.authorBlas-Rus, Noelia
dc.contributor.authorMartín-Cófreces, Noa Beatriz
dc.contributor.authorSánchez-Madrid, Francisco
dc.date.accessioned2019-06-28T14:27:45Z-
dc.date.available2019-06-28T14:27:45Z-
dc.date.issued2016
dc.identifier.citationInt Rev Cell Mol Biol.2016;(327):195-261
dc.identifier.issn1937-6448
dc.identifier.urihttps://hdl.handle.net/20.500.12530/25113-
dc.description.abstractThe immune synapse (IS) is a specialized structure established between different immune cells that fulfills several functions, including a role as a communication bridge. This intimate contact between a T cell and an antigen-presenting cell promotes the proliferation and differentiation of lymphocytes involved in the contact. T-cell activation requires the specific triggering of the T-cell receptor (TCR), which promotes the activation of different signaling pathways inducing the polarization of the T cell. During this process, different adhesion and signaling receptors reorganize at specialized membrane domains, concomitantly to the polarization of the tubulin and actin cytoskeletons, forming stable polarization platforms. The centrosome also moves toward the IS, driving the movement of different organelles, such as the biosynthetic, secretory, degrading machinery, and mitochondria, to sustain T-cell activation. A proper orchestration of all these events is essential for T-cell effector functions and the accomplishment of a complete immune response.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectT-cell receptor
dc.subjectasymmetric cell division
dc.subjectcentrosome
dc.subjectcytoskeleton
dc.subjectexosome
dc.subjectimmune synapse
dc.subjectmitochondria
dc.subjectsignaling
dc.subject.meshAnimals
dc.subject.meshCell Communication
dc.subject.meshCell Polarity
dc.subject.meshHumans
dc.subject.meshImmune System
dc.subject.meshLymphocytes
dc.subject.meshMembrane Microdomains
dc.subject.meshOrganelles
dc.titleOrchestrating Lymphocyte Polarity in Cognate Immune Cell-Cell Interactions.
dc.typeArtículo
dc.identifier.pubmedID27692176
dc.format.volume327
dc.format.page195-261
dc.identifier.journalInternational review of cell and molecular biology
dc.identifier.doi10.1016/bs.ircmb.2016.06.004
dc.identifier.pmcPMC5115617
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

Files in This Item:
File Description SizeFormat 
PMC5115617.pdf3.86 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.