Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/25224
Title: Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.
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Issue Date: 2016
Citation: Front Aging Neurosci.2016;(8):209
Abstract: Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects exerted by folate deprivation follow the same pattern in a mouse strain such as CBA/Ca, which is resistant to hearing impairment. Here, we show results of a long-term study on hearing carried out on CBA/Ca mice subjected to dietary folate deprivation. Systemic changes included decreased serum folate levels, hyperhomocysteinemia and signs of anemia in the group fed with folate-deficient (FD) diet. Initial signs of hearing loss were detected in this strain after 8-months of vitamin deficiency, and correlated with histological damage in the cochleae. In conclusion, the data presented reinforce the importance of adequate folic acid levels for the auditory system and suggest that the impact of dietary deficiencies may depend on the genetic background.
PMID: 27630560
URI: https://hdl.handle.net/20.500.12530/25224
Rights: openAccess
ISSN: 1663-4365
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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