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|Title:||Efficacy and safety of left atrial appendage closure versus medical treatment in atrial fibrillation: a network meta-analysis from randomised trials.|
Platelet Aggregation Inhibitors
Randomized Controlled Trials as Topic
Septal Occluder Device
|Abstract:||The effectiveness of vitamin K antagonist (VKA) versus placebo and antiplatelet therapy (APT) is well established for stroke prevention in atrial fibrillation (AF). Non-vitamin K antagonist oral anticoagulants (NOAC) are mostly superior to VKA in stroke and intracranial bleeding prevention. Recent randomised controlled trials (RCTs) suggested the non-inferiority of percutaneous left atrial appendage closure (LAAC) versus VKA. However, comparisons between LAAC versus placebo, APT or NOAC are lacking. The purpose of this network meta-analysis was to assess the efficacy and safety of LAAC compared with other strategies for stroke prevention in patients with AF.|
|Appears in Collections:||Hospitales > H. U. Clínico San Carlos > Artículos|
Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos
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