Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/25736
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dc.contributor.authorResino, Elena
dc.contributor.authorSan-Juan, Rafael
dc.contributor.authorAguado, Jose Maria
dc.date.accessioned2019-06-28T14:41:26Z-
dc.date.available2019-06-28T14:41:26Z-
dc.date.issued2016-07-14
dc.identifier.citationWorld J. Gastroenterol..2016 Jul;(22)26:5950-7
dc.identifier.urihttps://hdl.handle.net/20.500.12530/25736-
dc.description.abstractBacterial infection in the first month after liver transplantation is a frequent complication that poses a serious risk for liver transplant recipients as contributes substantially to increased length of hospitalization and hospital costs being a leading cause of death in this period. Most of these infections are caused by gram-negative bacilli, although gram-positive infections, especially Enterococcus sp. constitute an emerging infectious problem. This high rate of early postoperative infections after liver transplant has generated interest in exploring various prophylactic approaches to surmount this problem. One of these approaches is selective intestinal decontamination (SID). SID is a prophylactic strategy that consists of the administration of antimicrobials with limited anaerobicidal activity in order to reduce the burden of aerobic gram-negative bacteria and/or yeast in the intestinal tract and so prevent infections caused by these organisms. The majority of studies carried out to date have found SID to be effective in the reduction of gram-negative infection, but the effect on overall infection is limited due to a higher number of infection episodes by pathogenic enterococci and coagulase-negative staphylococci. However, difficulties in general extrapolation of the favorable results obtained in specific studies together with the potential risk of selection of multirresistant microorganisms has conditioned controversy about the routinely application of these strategies in liver transplant recipients.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectGram-negative bacterial infection
dc.subjectGram-positive bacterial infection
dc.subjectInfection
dc.subjectLiver transplant
dc.subjectMultirresistant
dc.subjectSelective intestinal decontamination
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshAntibiotic Prophylaxis
dc.subject.meshDecontamination
dc.subject.meshGram-Negative Bacterial Infections
dc.subject.meshGram-Positive Bacterial Infections
dc.subject.meshHumans
dc.subject.meshIntestines
dc.subject.meshPostoperative Complications
dc.subject.meshLiver Transplantation
dc.titleSelective intestinal decontamination for the prevention of early bacterial infections after liver transplantation.
dc.typeArtículo
dc.identifier.pubmedID27468189
dc.format.volume22
dc.format.page5950-7
dc.identifier.e-issn2219-2840
dc.identifier.journalWorld journal of gastroenterology
dc.identifier.doi10.3748/wjg.v22.i26.5950
dc.format.number26
dc.identifier.pmcPMC4948279
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos

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