Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study.

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Title:	Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study.
Authors:	Maurel, Joan López-Pousa, Antonio Calabuig, Silvia Bagué, Silvia Del Muro, Xavier Garcia Sanjuan, Xavier Rubió-Casadevall, Jordi Cuatrecasas, Miriam Martinez-Trufero, Javier Horndler, Carlos Fra, Joaquin Valverde, Claudia Redondo, Andrés Poveda, Andrés Sevilla, Isabel Lainez, Nuria Rubini, Michele García-Albéniz, Xabier Martín-Broto, Javier de Alava, Enrique View more
Issue Date:	2016
Citation:	Clin Sarcoma Res.2016;(6):10
Abstract:	Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon 11 mutated tumors. We evaluated the immunohistochemical (IHC) expression of p-IGF1R (Y1316) and MMP3 as predictors of PFS or overall survival (OS).
PMID:	27358721
URI:	https://hdl.handle.net/20.500.12530/26022
Rights:	openAccess
ISSN:	2045-3329
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Hospitales > H. U. La Paz > Artículos

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