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https://hdl.handle.net/20.500.12530/27004| Title: | SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer. | |
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| Issue Date: | Jan-2017 | |
| Citation: | J. Gastroenterol..2017 Jan;(52)1:39-49 | |
| Abstract: | Intestinal metaplasia (IM) is a gastric cancer precursor lesion (GCPL) and an extremely high risk factor for progression to gastric cancer (GC). Clinical guidelines recommend that patients with extensive IM undergo a gastroscopy every 3 years. However, protein biomarkers that indicate a transition from IM to GC are lacking. Our group recently identified an interferon-alpha (IFNα)-responsive gene, Schlafen 4 (Slfn4), in immune cells that correlates with metaplastic changes in Helicobacter-infected mice. We therefore tested the hypothesis that a human homolog of Slfn4, namely, Schlafen 5 (SLFN5), correlates with progression of GCPL to GC. | |
| PMID: | 27032393 | |
| URI: | https://hdl.handle.net/20.500.12530/27004 | |
| Rights: | openAccess | |
| Appears in Collections: | Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos Fundaciones e Institutos de Investigación > FIB H. U. Príncipe de Asturias > Artículos | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PMC5045746.pdf | 1.92 MB | Adobe PDF |  View/Open |
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