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Title: Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog.
Issue Date: Mar-2016
Citation: Med Mycol Case Rep.2016 Mar;(11):9-12
Abstract: Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene, but the latter displayed increased azole minimum inhibitory concentrations. A novel frameshift mutation in ERG3 was found in some isolates recovered after resistance development, so it appears unlikely that this mutation is responsible for multi-azole resistance.
PMID: 26949597
Rights: openAccess
ISSN: 2211-7539
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

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