Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/27818
Title: Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells.
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Issue Date: 2016
Citation: PLoS ONE.2016;(11)1:e0145760
Abstract: HIV-1 has proved to infect regulatory T cells (Treg) modifying their phenotype and impairing their suppressive capacity. As Treg cells are a crucial component in the preservation of the immune homeostasis, we researched that the antiviral capacity of carboxilan dendrimers prevents the HIV-1 infection of Treg and their effects. The phenotype and suppressive capacity of Treg treated or non-treated with carbosilane dendrimers were studied by flow cytometry. Treated and non-treated Treg from healthy donors were infected with HIV-1NL4.3. The infection of Treg cells by HIV-1, and protective effect of two dendrimers were determined by measuring antigen p24gag in the supernatant of the culture and intracellular.
PMID: 26785250
URI: https://hdl.handle.net/20.500.12530/27818
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

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