Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/28631
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dc.contributor.authorPina-Camacho, Laura
dc.contributor.authorDel Rey-Mejías, Ángel
dc.contributor.authorJanssen, Joost
dc.contributor.authorBioque, Miquel
dc.contributor.authorGonzález-Pinto, Ana
dc.contributor.authorArango, Celso
dc.contributor.authorLobo, Antonio
dc.contributor.authorSarró, Salvador
dc.contributor.authorDesco, Manuel
dc.contributor.authorSanjuan, Julio
dc.contributor.authorLacalle-Aurioles, Maria
dc.contributor.authorCuesta, Manuel J
dc.contributor.authorSaiz-Ruiz, Jerónimo
dc.contributor.authorBernardo, Miguel
dc.contributor.authorParellada, Mara
dc.date.accessioned2019-06-28T15:35:54Z-
dc.date.available2019-06-28T15:35:54Z-
dc.date.issued2016-03
dc.identifier.citationSchizophr Bull.2016 Mar;(42)2:344-57
dc.identifier.urihttps://hdl.handle.net/20.500.12530/28631-
dc.description.abstractBrain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients with schizophrenia spectrum disorders (SSD), affective psychoses (AFP), and HC. Earlier SSD cases (ie, FEP before 15-20 y) showed significant volume and thickness deficits in frontal lobe, volume deficits in temporal lobe, and volume enlargements in ventricular system and basal ganglia. First-episode AFP patients had smaller cingulate cortex volume and thicker temporal cortex only at early age at FEP (before 18-20 y). The AFP group also had age-constant (12-35-y age span) volume enlargements in the frontal and parietal lobe. Our study suggests that age at first episode modulates the structural brain abnormalities found in FEP patients in a nonlinear and diagnosis-dependent manner. Future MRI studies should take these results into account when interpreting samples with different ages at onset and diagnosis.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectMRI
dc.subjectage at onset
dc.subjectbipolar disorder
dc.subjectcortical thickness
dc.subjectcortical volume
dc.subjectfirst-episode psychosis
dc.subjectschizophrenia
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAge of Onset
dc.subject.meshCase-Control Studies
dc.subject.meshCerebral Cortex
dc.subject.meshChild
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshGray Matter
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshPsychotic Disorders
dc.subject.meshSchizophrenia
dc.subject.meshYoung Adult
dc.titleAge at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis.
dc.typeArtículo
dc.identifier.pubmedID26371339
dc.format.volume42
dc.format.page344-57
dc.identifier.e-issn1745-1701
dc.identifier.journalSchizophrenia bulletin
dc.identifier.doi10.1093/schbul/sbv128
dc.format.number2
dc.identifier.pmcPMC4753597
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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