Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/29909
Title: Role of GALNT12 in the genetic predisposition to attenuated adenomatous polyposis syndrome.
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Issue Date: 2017
Citation: Lorca V, Rueda D, Martín-Morales L, Poves C, Fernández-Aceñero MJ, Ruiz-Ponte C, et al. Role of GALNT12 in the genetic predisposition to attenuated adenomatous polyposis syndrome. PLoS One. 2017;12(11):e0187312
Abstract: The involvement of GALNT12 in colorectal carcinogenesis has been demonstrated but it is not clear to what extent it is implicated in familial CRC susceptibility. Partially inactivating variant, NM_024642.4:c.907G>A, p.(D303N), has been previously detected in familial CRC and proposed as the causative risk allele. Since phenotypes of the described carrier families showed not only CRC but also a polyp history, we hypothesized that GALNT12 could be involved in adenoma predisposition and consequently, in hereditary polyposis CRC syndromes. For that purpose, we have screened the GALNT12 gene in germline DNA from 183 unrelated attenuated polyposis patients. c.907G>A, p.(D303N) was detected in 4 cases (MAF = 1.1%) and no other candidate variants were found. After segregation studies, LOH analyses, glycosylation pattern tests and case-control studies, our results did not support the role of c.907G>A, p.(D303N) as a high-penetrance risk allele for polyposis CRC.
PMID: 29095867
URI: https://hdl.handle.net/20.500.12530/29909
Rights: openAccess
Appears in Collections:Hospitales > H. U. de Móstoles > Artículos
Hospitales > H. U. Clínico San Carlos > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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