Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/29943
Title: Treating KRAS-mutant NSCLC: latest evidence and clinical consequences.
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Issue Date: Sep-2017
Citation: Ther Adv Med Oncol.2017 Sep;(9)9:589-597
Abstract: KRAS mutations represent one of the most prevalent oncogenic driver mutations in non-small cell lung cancer (NSCLC). For many years we have unsuccessfully addressed KRAS mutation as a unique disease. The recent widespread use of comprehensive genomic profiling has identified different subgroups with prognostic implications. Moreover, recent data recognizing the distinct biology and therapeutic vulnerabilities of different KRAS subgroups have allowed us to explore different treatment approaches. Small molecules that selectively inhibit KRAS G12C or use of immune checkpoint inhibitors based on co-mutation status are some examples which anticipate that personalized treatment for this challenging disease is finally on the horizon.
PMID: 29081842
URI: https://hdl.handle.net/20.500.12530/29943
Rights: openAccess
ISSN: 1758-8340
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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