Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/29943
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGarrido, Pilar
dc.contributor.authorOlmedo, María Eugenia
dc.contributor.authorGómez, Ana
dc.contributor.authorPaz Ares, Luis
dc.contributor.authorLópez-Ríos, Fernando
dc.contributor.authorRosa-Rosa, Juan Manuel
dc.contributor.authorPalacios, José
dc.date.accessioned2019-06-28T16:03:10Z-
dc.date.available2019-06-28T16:03:10Z-
dc.date.issued2017-09
dc.identifier.citationTher Adv Med Oncol.2017 Sep;(9)9:589-597
dc.identifier.issn1758-8340
dc.identifier.urihttps://hdl.handle.net/20.500.12530/29943-
dc.description.abstractKRAS mutations represent one of the most prevalent oncogenic driver mutations in non-small cell lung cancer (NSCLC). For many years we have unsuccessfully addressed KRAS mutation as a unique disease. The recent widespread use of comprehensive genomic profiling has identified different subgroups with prognostic implications. Moreover, recent data recognizing the distinct biology and therapeutic vulnerabilities of different KRAS subgroups have allowed us to explore different treatment approaches. Small molecules that selectively inhibit KRAS G12C or use of immune checkpoint inhibitors based on co-mutation status are some examples which anticipate that personalized treatment for this challenging disease is finally on the horizon.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectKRAS
dc.subjectgenomic profiling
dc.subjectnon-small cell lung cancer
dc.subjectpredictive factor
dc.subjectprognostic factor
dc.titleTreating KRAS-mutant NSCLC: latest evidence and clinical consequences.
dc.typeArtículo
dc.identifier.pubmedID29081842
dc.format.volume9
dc.format.page589-597
dc.identifier.journalTherapeutic advances in medical oncology
dc.identifier.doi10.1177/1758834017719829
dc.format.number9
dc.identifier.pmcPMC5564881
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

Files in This Item:
File Description SizeFormat 
PMC5564881.pdf500.76 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.