Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/30731
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dc.contributor.authorPérez-Rueda, María
dc.contributor.authorHernández-Cabrera, Michele
dc.contributor.authorFrancés-Urmeneta, Adela
dc.contributor.authorAngel-Moreno, Alfonso
dc.contributor.authorPisos-Álamo, Elena
dc.contributor.authorJaén-Sánchez, Nieves
dc.contributor.authorCarranza-Rodríguez, Cristina
dc.contributor.authorPérez-Arellano, Jose-Luis
dc.date.accessioned2019-06-28T16:22:02Z-
dc.date.available2019-06-28T16:22:02Z-
dc.date.issued2017-10
dc.identifier.citationAm. J. Trop. Med. Hyg..2017 Oct;(97)4:1072-1077
dc.identifier.urihttps://hdl.handle.net/20.500.12530/30731-
dc.description.abstractImmune reconstitution inflammatory syndrome (IRIS) includes a group of potentially serious inflammatory processes that may be present in HIV-infected patients after initiating highly active antiretroviral therapy (HAART). Paradoxical IRIS is a worsening of symptoms, after an overwhelming response to a previously diagnosed opportunistic infection (OI); unmasking IRIS reveals a previously occult OI. The main objective of the study was to describe the epidemiological, clinical, and outcome data of HIV-infected immigrants, stratified according to high- or low-income countries of origin, who developed IRIS and to compare them with native-born Spanish patients. This retrospective study reviewed all patients with HIV infection admitted to the Unit of Infectious Diseases and Tropical Medicine between 1998 and 2014. IRIS was identified in 25/138 (18%) immigrant patients and 24/473 (5%) native-born Spanish patients infected with HIV. Most cases, 19/25 (76%), were of unmasking IRIS. The time elapsed between initiation of HAART and development of IRIS was significantly longer in patients with unmasking versus paradoxical IRIS. OIs, in particular due to mycobacteria, were the most frequently involved processes. Twenty percent of patients died. The comparison of immigrant and native-born patients found significant differences for both IRIS type (higher incidence of paradoxical forms among immigrants) and for the absence of malignancies in native-born patients. No significant differences were found when the data of immigrants from low- and high-income countries were compared.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAIDS-Related Opportunistic Infections
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAnti-HIV Agents
dc.subject.meshEmigrants and Immigrants
dc.subject.meshFemale
dc.subject.meshHIV Infections
dc.subject.meshHumans
dc.subject.meshImmune Reconstitution Inflammatory Syndrome
dc.subject.meshIncidence
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRetrospective Studies
dc.subject.meshSpain
dc.titleImmune Reconstitution Inflammatory Syndrome in HIV-Infected Immigrants.
dc.typeArtículo
dc.identifier.pubmedID28820685
dc.format.volume97
dc.format.page1072-1077
dc.identifier.e-issn1476-1645
dc.identifier.journalThe American journal of tropical medicine and hygiene
dc.identifier.doi10.4269/ajtmh.16-0773
dc.format.number4
dc.identifier.pmcPMC5637585
dc.pubmedtypeComparative Study
dc.pubmedtypeJournal Article
Appears in Collections:Hospitales > H. U. Puerta de Hierro Majadahonda > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Puerta de Hierro-Segovia de Arana > Artículos

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