Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/31002
Title: Insights in Anaphylaxis and Clonal Mast Cell Disorders.
Authors: González-de-Olano, David
Álvarez-Twose, Iván
Keywords: 
Issue Date: 2017
Citation: Front Immunol.2017;(8):792
Abstract: The prevalence of anaphylaxis among patients with clonal mast cell disorders (MCD) is clearly higher comparing to the general population. Due to a lower frequency of symptoms outside of acute episodes, clonal MCD in the absence of skin lesions might sometimes be difficult to identify which may lead to underdiagnosis, and anaphylaxis is commonly the presenting symptom in these patients. Although the release of mast cell (MC) mediators upon MC activation might present with a wide variety of symptoms, particular clinical features typically characterize MC mediator release episodes in patients with clonal MCD without skin involvement. Final diagnosis requires a bone marrow study, and it is recommended that this should be done in reference centers. In this article, we address the main triggers for anaphylaxis, risk factors, clinical presentation, diagnosis, and management of patients with MC activation syndromes (MCASs), with special emphasis on clonal MCAS [systemic mastocytosis and mono(clonal) MC activations syndromes].
PMID: 28740494
URI: https://hdl.handle.net/20.500.12530/31002
Rights: openAccess
ISSN: 1664-3224
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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