Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial.

Davies, Michael A; Saiag, Philippe; Robert, Caroline; Grob, Jean-Jacques; Flaherty, Keith T; Arance, Ana; Chiarion-Sileni, Vanna; Thomas, Luc; Lesimple, Thierry; Mortier, Laurent; Moschos, Stergios J; Hogg, David; Márquez-Rodas, Iván; Del Vecchio, Michele; Lebbé, Céleste; Meyer, Nicolas; Zhang, Ying; Huang, Yingjie; Mookerjee, Bijoyesh; Long, Georgina V

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/31583

Title:	Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial.
Authors:	Davies, Michael A Saiag, Philippe Robert, Caroline Grob, Jean-Jacques Flaherty, Keith T Arance, Ana Chiarion-Sileni, Vanna Thomas, Luc Lesimple, Thierry Mortier, Laurent Moschos, Stergios J Hogg, David Márquez-Rodas, Iván Del Vecchio, Michele Lebbé, Céleste Meyer, Nicolas Zhang, Ying Huang, Yingjie Mookerjee, Bijoyesh Long, Georgina V View more
Mesh:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Brain Neoplasms Female Fever Headache Humans Imidazoles Magnetic Resonance Imaging Male Melanoma Middle Aged Mutation Oximes Prospective Studies Proto-Oncogene Proteins B-raf Pyridones Pyrimidinones Stroke Volume Young Adult View more
Issue Date:	2017
Citation:	Lancet Oncol..2017 07;(18)7:863-873
Abstract:	Dabrafenib plus trametinib improves clinical outcomes in BRAFV600-mutant metastatic melanoma without brain metastases; however, the activity of dabrafenib plus trametinib has not been studied in active melanoma brain metastases. Here, we report results from the phase 2 COMBI-MB trial. Our aim was to build on the current body of evidence of targeted therapy in melanoma brain metastases through an evaluation of dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases.
PMID:	28592387
URI:	https://hdl.handle.net/20.500.12530/31583
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

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