Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/32150
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dc.contributor.authorPerez-Rodriguez, M Mercedes
dc.contributor.authorNew, Antonia S
dc.contributor.authorGoldstein, Kim E
dc.contributor.authorRosell, Daniel
dc.contributor.authorYuan, Qiaoping
dc.contributor.authorZhou, Zhifeng
dc.contributor.authorHodgkinson, Colin
dc.contributor.authorGoldman, David
dc.contributor.authorSiever, Larry J
dc.contributor.authorHazlett, Erin A
dc.date.accessioned2019-06-28T16:55:49Z-
dc.date.available2019-06-28T16:55:49Z-
dc.date.issued2017-05-30
dc.identifier.citationPsychiatry Res Neuroimaging.2017 May;(263):85-92
dc.identifier.urihttps://hdl.handle.net/20.500.12530/32150-
dc.description.abstractA deficit in amygdala habituation to repeated emotional stimuli may be an endophenotype of disorders characterized by emotion dysregulation, such as borderline personality disorder (BPD). Amygdala reactivity to emotional stimuli is genetically modulated by brain-derived neurotrophic factor (BDNF) variants. Whether amygdala habituation itself is also modulated by BDNF genotypes remains unknown. We used imaging-genetics to examine the effect of BDNF Val66Met genotypes on amygdala habituation to repeated emotional stimuli. We used functional magnetic resonance imaging (fMRI) in 57 subjects (19 BPD patients, 18 patients with schizotypal personality disorder [SPD] and 20 healthy controls [HC]) during a task involving viewing of unpleasant, neutral, and pleasant pictures, each presented twice to measure habituation. Amygdala responses across genotypes (Val66Met SNP Met allele-carriers vs. Non-Met carriers) and diagnoses (HC, BPD, SPD) were examined with ANOVA. The BDNF 66Met allele was significantly associated with a deficit in amygdala habituation, particularly for emotional pictures. The association of the 66Met allele with a deficit in habituation to unpleasant emotional pictures remained significant in the subsample of BPD patients. Using imaging-genetics, we found preliminary evidence that deficient amygdala habituation may be modulated by BDNF genotype.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectAmygdala
dc.subjectBDNF
dc.subjectBorderline personality disorder
dc.subjectEmotion regulation
dc.subjectExtinction
dc.subjectHabituation
dc.subject.meshAdult
dc.subject.meshAlleles
dc.subject.meshAmygdala
dc.subject.meshBrain-Derived Neurotrophic Factor
dc.subject.meshEmotions
dc.subject.meshFemale
dc.subject.meshHabituation, Psychophysiologic
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMethionine
dc.subject.meshMiddle Aged
dc.subject.meshPhotic Stimulation
dc.subject.meshSchizotypal Personality Disorder
dc.subject.meshValine
dc.subject.meshGenotype
dc.titleBrain-derived neurotrophic factor Val66Met genotype modulates amygdala habituation.
dc.typeArtículo
dc.identifier.pubmedID28371657
dc.format.volume263
dc.format.page85-92
dc.identifier.e-issn1872-7506
dc.identifier.journalPsychiatry research. Neuroimaging
dc.identifier.doi10.1016/j.pscychresns.2017.03.008
dc.identifier.pmcPMC5856456
dc.pubmedtypeJournal Article
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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