Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/32242
Title: Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Authors: 
Phelan, Catherine M
Kuchenbaecker, Karoline B
Tyrer, Jonathan P
Kar, Siddhartha P
Lawrenson, Kate
Winham, Stacey J
Dennis, Joe
Pirie, Ailith
Riggan, Marjorie J
Chornokur, Ganna
Earp, Madalene A
Lyra, Paulo C
Lee, Janet M
Coetzee, Simon
Beesley, Jonathan
McGuffog, Lesley
Soucy, Penny
Dicks, Ed
Lee, Andrew
Barrowdale, Daniel
Lecarpentier, Julie
Leslie, Goska
Aalfs, Cora M
Aben, Katja K H
Adams, Marcia
Adlard, Julian
Andrulis, Irene L
Anton-Culver, Hoda
Antonenkova, Natalia
Aravantinos, Gerasimos
Arnold, Norbert
Arun, Banu K
Arver, Brita
Azzollini, Jacopo
Balmaña, Judith
Banerjee, Susana N
Barjhoux, Laure
Barkardottir, Rosa B
Bean, Yukie
Beckmann, Matthias W
Beeghly-Fadiel, Alicia
Benitez, Javier
Bermisheva, Marina
Bernardini, Marcus Q
Birrer, Michael J
Bjorge, Line
Black, Amanda
Blankstein, Kenneth
Blok, Marinus J
Bodelon, Clara
Bogdanova, Natalia
Bojesen, Anders
Bonanni, Bernardo
Borg, Åke
Bradbury, Angela R
Brenton, James D
Brewer, Carole
Brinton, Louise
Broberg, Per
Brooks-Wilson, Angela
Bruinsma, Fiona
Brunet, Joan
Buecher, Bruno
Butzow, Ralf
Buys, Saundra S
Caldes, Trinidad
Caligo, Maria A
Campbell, Ian
Cannioto, Rikki
Carney, Michael E
Cescon, Terence
Chan, Salina B
Chang-Claude, Jenny
Chanock, Stephen
Chen, Xiao Qing
Chiew, Yoke-Eng
Chiquette, Jocelyne
Chung, Wendy K
Claes, Kathleen B M
Conner, Thomas
Cook, Linda S
Cook, Jackie
Cramer, Daniel W
Cunningham, Julie M
D'Aloisio, Aimee A
Daly, Mary B
Damiola, Francesca
Damirovna, Sakaeva Dina
Dansonka-Mieszkowska, Agnieszka
Dao, Fanny
Davidson, Rosemarie
DeFazio, Anna
Delnatte, Capucine
Doheny, Kimberly F
Diez, Orland
Ding, Yuan Chun
Doherty, Jennifer Anne
Domchek, Susan M
Dorfling, Cecilia M
Dörk, Thilo
Dossus, Laure
Duran, Mercedes
Dürst, Matthias
Dworniczak, Bernd
Eccles, Diana
Edwards, Todd
Eeles, Ros
Eilber, Ursula
Ejlertsen, Bent
Ekici, Arif B
Ellis, Steve
Elvira, Mingajeva
Eng, Kevin H
Engel, Christoph
Evans, D Gareth
Fasching, Peter A
Ferguson, Sarah
Ferrer, Sandra Fert
Flanagan, James M
Fogarty, Zachary C
Fortner, Renée T
Fostira, Florentia
Foulkes, William D
Fountzilas, George
Fridley, Brooke L
Friebel, Tara M
Friedman, Eitan
Frost, Debra
Ganz, Patricia A
Garber, Judy
García, María J
Garcia-Barberan, Vanesa
Gehrig, Andrea
Gentry-Maharaj, Aleksandra
Gerdes, Anne-Marie
Giles, Graham G
Glasspool, Rosalind
Glendon, Gord
Godwin, Andrew K
Goldgar, David E
Goranova, Teodora
Gore, Martin
Greene, Mark H
Gronwald, Jacek
Gruber, Stephen
Hahnen, Eric
Haiman, Christopher A
Håkansson, Niclas
Hamann, Ute
Hansen, Thomas V O
Harrington, Patricia A
Harris, Holly R
Hauke, Jan
Hein, Alexander
Henderson, Alex
Hildebrandt, Michelle A T
Hillemanns, Peter
Hodgson, Shirley
Høgdall, Claus K
Høgdall, Estrid
Hogervorst, Frans B L
Holland, Helene
Hooning, Maartje J
Hosking, Karen
Huang, Ruea-Yea
Hulick, Peter J
Hung, Jillian
Hunter, David J
Huntsman, David G
Huzarski, Tomasz
Imyanitov, Evgeny N
Isaacs, Claudine
Iversen, Edwin S
Izatt, Louise
Izquierdo, Angel
Jakubowska, Anna
James, Paul
Janavicius, Ramunas
Jernetz, Mats
Jensen, Allan
Jensen, Uffe Birk
John, Esther M
Johnatty, Sharon
Jones, Michael E
Kannisto, Päivi
Karlan, Beth Y
Karnezis, Anthony
Kast, Karin
Kennedy, Catherine J
Khusnutdinova, Elza
Kiemeney, Lambertus A
Kiiski, Johanna I
Kim, Sung-Won
Kjaer, Susanne K
Köbel, Martin
Kopperud, Reidun K
Kruse, Torben A
Kupryjanczyk, Jolanta
Kwong, Ava
Laitman, Yael
Lambrechts, Diether
Larrañaga, Nerea
Larson, Melissa C
Lazaro, Conxi
Le, Nhu D
Le Marchand, Loic
Lee, Jong Won
Lele, Shashikant B
Leminen, Arto
Leroux, Dominique
Lester, Jenny
Lesueur, Fabienne
Levine, Douglas A
Liang, Dong
Liebrich, Clemens
Lilyquist, Jenna
Lipworth, Loren
Lissowska, Jolanta
Lu, Karen H
Lubinński, Jan
Luccarini, Craig
Lundvall, Lene
Mai, Phuong L
Mendoza-Fandiño, Gustavo
Manoukian, Siranoush
Massuger, Leon F A G
May, Taymaa
Mazoyer, Sylvie
McAlpine, Jessica N
McGuire, Valerie
McLaughlin, John R
McNeish, Iain
Meijers-Heijboer, Hanne
Meindl, Alfons
Menon, Usha
Mensenkamp, Arjen R
Merritt, Melissa A
Milne, Roger L
Mitchell, Gillian
Modugno, Francesmary
Moes-Sosnowska, Joanna
Moffitt, Melissa
Montagna, Marco
Moysich, Kirsten B
Mulligan, Anna Marie
Musinsky, Jacob
Nathanson, Katherine L
Nedergaard, Lotte
Ness, Roberta B
Neuhausen, Susan L
Nevanlinna, Heli
Niederacher, Dieter
Nussbaum, Robert L
Odunsi, Kunle
Olah, Edith
Olopade, Olufunmilayo I
Olsson, Håkan
Olswold, Curtis
O'Malley, David M
Ong, Kai-Ren
Onland-Moret, N Charlotte
Orr, Nicholas
Orsulic, Sandra
Osorio, Ana
Palli, Domenico
Papi, Laura
Park-Simon, Tjoung-Won
Paul, James
Pearce, Celeste L
Pedersen, Inge Søkilde
Peeters, Petra H M
Peissel, Bernard
Peixoto, Ana
Pejovic, Tanja
Pelttari, Liisa M
Permuth, Jennifer B
Peterlongo, Paolo
Pezzani, Lidia
Pfeiler, Georg
Phillips, Kelly-Anne
Piedmonte, Marion
Pike, Malcolm C
Piskorz, Anna M
Poblete, Samantha R
Pocza, Timea
Poole, Elizabeth M
Poppe, Bruce
Porteous, Mary E
Prieur, Fabienne
Prokofyeva, Darya
Pugh, Elizabeth
Pujana, Miquel Angel
Pujol, Pascal
Radice, Paolo
Rantala, Johanna
Rappaport-Fuerhauser, Christine
Rennert, Gad
Rhiem, Kerstin
Rice, Patricia
Richardson, Andrea
Robson, Mark
Rodriguez, Gustavo C
Rodríguez-Antona, Cristina
Romm, Jane
Rookus, Matti A
Rossing, Mary Anne
Rothstein, Joseph H
Rudolph, Anja
Runnebaum, Ingo B
Salvesen, Helga B
Sandler, Dale P
Schoemaker, Minouk J
Senter, Leigha
Setiawan, V Wendy
Severi, Gianluca
Sharma, Priyanka
Shelford, Tameka
Siddiqui, Nadeem
Side, Lucy E
Sieh, Weiva
Singer, Christian F
Sobol, Hagay
Song, Honglin
Southey, Melissa C
Spurdle, Amanda B
Stadler, Zsofia
Steinemann, Doris
Stoppa-Lyonnet, Dominique
Sucheston-Campbell, Lara E
Sukiennicki, Grzegorz
Sutphen, Rebecca
Sutter, Christian
Swerdlow, Anthony J
Szabo, Csilla I
Szafron, Lukasz
Tan, Yen Y
Taylor, Jack A
Tea, Muy-Kheng
Teixeira, Manuel R
Teo, Soo-Hwang
Terry, Kathryn L
Thompson, Pamela J
Thomsen, Liv Cecilie Vestrheim
Thull, Darcy L
Tihomirova, Laima
Tinker, Anna V
Tischkowitz, Marc
Tognazzo, Silvia
Toland, Amanda Ewart
Tone, Alicia
Trabert, Britton
Travis, Ruth C
Trichopoulou, Antonia
Tung, Nadine
Tworoger, Shelley S
van Altena, Anne M
Van Den Berg, David
van der Hout, Annemarie H
van der Luijt, Rob B
Van Heetvelde, Mattias
Van Nieuwenhuysen, Els
van Rensburg, Elizabeth J
Vanderstichele, Adriaan
Varon-Mateeva, Raymonda
Vega, Ana
Edwards, Digna Velez
Vergote, Ignace
Vierkant, Robert A
Vijai, Joseph
Vratimos, Athanassios
Walker, Lisa
Walsh, Christine
Wand, Dorothea
Wang-Gohrke, Shan
Wappenschmidt, Barbara
Webb, Penelope M
Weinberg, Clarice R
Weitzel, Jeffrey N
Wentzensen, Nicolas
Whittemore, Alice S
Wijnen, Juul T
Wilkens, Lynne R
Wolk, Alicja
Woo, Michelle
Wu, Xifeng
Wu, Anna H
Yang, Hannah
Yannoukakos, Drakoulis
Ziogas, Argyrios
Zorn, Kristin K
Narod, Steven A
Easton, Douglas F
Amos, Christopher I
Schildkraut, Joellen M
Ramus, Susan J
Ottini, Laura
Goodman, Marc T
Park, Sue K
Kelemen, Linda E
Risch, Harvey A
Thomassen, Mads
Offit, Kenneth
Simard, Jacques
Schmutzler, Rita Katharina
Hazelett, Dennis
Monteiro, Alvaro N
Couch, Fergus J
Berchuck, Andrew
Chenevix-Trench, Georgia
Goode, Ellen L
Sellers, Thomas A
Gayther, Simon A
Antoniou, Antonis C
Pharoah, Paul D P
Mesh: 
Issue Date: May-2017
Citation: Nat. Genet..2017 May;(49)5:680-691
Abstract: To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
PMID: 28346442
URI: https://hdl.handle.net/20.500.12530/32242
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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