Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/32288
Title: Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection.
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Issue Date: 1-Oct-2017
Citation: Nephrol. Dial. Transplant..2017 Oct;(32)10:1645-1655
Abstract: Cisplatin is a potent chemotherapeutic drug whose nephrotoxic effect is a major complication and a dose-limiting factor for antitumoral therapy. There is much evidence that inflammation contributes to the pathogenesis of cisplatin-induced nephrotoxicity. We found that cilastatin, a renal dehydropeptidase-I inhibitor, has protective effects in vitro and in vivo against cisplatin-induced renal damage by inhibiting apoptosis and oxidation. Here, we investigated the potential use of cilastatin to protect against cisplatin-induced kidney injury and inflammation in rats.
PMID: 28340076
URI: https://hdl.handle.net/20.500.12530/32288
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

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