Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/32605
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dc.contributor.authorCastro-Sánchez, P
dc.contributor.authorRamirez-Munoz, R
dc.contributor.authorLamana, A
dc.contributor.authorOrtiz, A
dc.contributor.authorGonzález-Álvaro, I
dc.contributor.authorRoda-Navarro, P
dc.date.accessioned2019-06-28T17:04:09Z-
dc.date.available2019-06-28T17:04:09Z-
dc.date.issued2017
dc.identifier.citationClin. Exp. Immunol..2017 07;(189)1:113-119
dc.identifier.urihttps://hdl.handle.net/20.500.12530/32605-
dc.description.abstractPhosphotyrosine phosphatases (PTPs) control phosphorylation levels and, consequently, regulate the output of intracellular signalling networks in health and disease. Despite the high number of PTPs expressed in CD4 T cells and their involvement in autoimmunity, information about the expression profile of PTPs in these cells has not been obtained in patients diagnosed with autoimmune diseases. Here, we compare the expression profile of PTPs in CD4 T cells of healthy volunteers and patients submitted to an early arthritis clinic, due to suspicion of rheumatoid arthritis, an autoimmune disease mediated by CD4 T cells. We found lower transcript levels of the mitogen-activated protein kinase (MAPK) phosphatase dual-specific phosphatase-7 (DUSP7) and the cell division cycle-25B (CDC25B) in T cells of patients. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of the disease. Low levels of CDC25B might contribute to the progression of the autoimmune arthritis and/or might be consequence of the inflammatory environment in the active disease. The possible role of DUSP7 and CDC25B as biomarkers of the disease in clinical protocols is discussed.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectCD4 T cells
dc.subjectCDC25B
dc.subjectDUSP7
dc.subjectPTPs
dc.subjectearly arthritis
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshArthritis
dc.subject.meshAutoimmune Diseases
dc.subject.meshBiomarkers
dc.subject.meshCD4-Positive T-Lymphocytes
dc.subject.meshDual-Specificity Phosphatases
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPhosphorylation
dc.subject.meshProspective Studies
dc.subject.meshRNA, Messenger
dc.subject.meshSpain
dc.subject.meshcdc25 Phosphatases
dc.titlemRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis.
dc.typeArtículo
dc.identifier.pubmedID28253537
dc.format.volume189
dc.format.page113-119
dc.identifier.e-issn1365-2249
dc.identifier.journalClinical and experimental immunology
dc.identifier.doi10.1111/cei.12953
dc.format.number1
dc.identifier.pmcPMC5461094
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos

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