Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/32764
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dc.contributor.authorGonzález-Tajuelo, Rafael
dc.contributor.authorSilván, Javier
dc.contributor.authorPérez-Frías, Alicia
dc.contributor.authorde la Fuente-Fernández, María
dc.contributor.authorTejedor, Reyes
dc.contributor.authorEspartero-Santos, Marina
dc.contributor.authorVicente-Rabaneda, Esther
dc.contributor.authorJuarranz, Ángeles
dc.contributor.authorMuñoz-Calleja, Cecilia
dc.contributor.authorCastañeda, Santos
dc.contributor.authorGamallo, Carlos
dc.contributor.authorUrzainqui, Ana
dc.date.accessioned2019-06-28T17:08:02Z-
dc.date.available2019-06-28T17:08:02Z-
dc.date.issued2017
dc.identifier.citationSci Rep.2017 02;(7):41841
dc.identifier.urihttps://hdl.handle.net/20.500.12530/32764-
dc.description.abstractMice deficient in P-Selectin presented altered immunity/tolerance balance. We have observed that the absence of P-Selectin promotes splenomegaly with reduced naïve T cell population, elevated activated/effector T cell subset, increased germinal center B and Tfh populations and high production of autoreactive antibodies. Moreover, 1.5-3-month-old P-selectin KO mice showed reduced IL-10-producing leukocytes in blood and a slightly reduced Treg population in the skin. With aging and, coinciding with disease severity, there is an increase in the IL17+ circulating and dermal T cell subpopulations and reduction of dermal Treg. As a consequence, P-Selectin deficient mice developed a progressive autoimmune syndrome showing skin alterations characteristic of lupus prone mice and elevated circulating autoantibodies, including anti-dsDNA. Similar to human SLE, disease pathogenesis was characterized by deposition of immune complexes in the dermoepidermal junction and renal glomeruli, and a complex pattern of autoantibodies. More important, skin biopsies of cutaneous lupus erythematosus patients did not show increased expression of P-Selectin, as described for other inflammatory diseases, and the number of vessels expressing P-Selectin was reduced.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAnimals
dc.subject.meshAutoantibodies
dc.subject.meshFemale
dc.subject.meshGerminal Center
dc.subject.meshHumans
dc.subject.meshInterleukin-10
dc.subject.meshInterleukin-17
dc.subject.meshLupus Erythematosus, Cutaneous
dc.subject.meshLymphocyte Subsets
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred C57BL
dc.subject.meshP-Selectin
dc.subject.meshSkin
dc.subject.meshSpleen
dc.subject.meshT-Lymphocytes
dc.subject.meshImmune Tolerance
dc.titleP-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus.
dc.typeArtículo
dc.identifier.pubmedID28150814
dc.format.volume7
dc.format.page41841
dc.identifier.e-issn2045-2322
dc.identifier.journalScientific reports
dc.identifier.doi10.1038/srep41841
dc.identifier.pmcPMC5288776
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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