Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/33148

Title:	Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.
Authors:	Martínez-Revelles, Sonia García-Redondo, Ana B Avendaño, María S Varona, Saray Palao, Teresa Orriols, Mar Roque, Fernanda R Fortuño, Ana Touyz, Rhian M Martínez-González, Jose Salaices, Mercedes Rodríguez, Cristina Briones, Ana M View more
Keywords:	NADPH oxidases extracellular matrix free radicals microvascular mitochondria tissue repair and remodeling View more
Mesh:	Animals Disease Models, Animal Elastin Extracellular Matrix Proteins Hypertension Male Mice Oxidative Stress Protein-Lysine 6-Oxidase Rats p38 Mitogen-Activated Protein Kinases Signal Transduction Vascular Stiffness View more
Issue Date:	1-Sep-2017
Citation:	Antioxid. Redox Signal..2017 Sep;(27)7:379-397
Abstract:	Vascular stiffness, structural elastin abnormalities, and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin crosslinking enzyme that produces H2O2 as a by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness, and elastin.
PMID:	28010122
URI:	https://hdl.handle.net/20.500.12530/33148
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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