Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/34289
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dc.contributor.authorMorgado-Pascual, Jose Luis
dc.contributor.authorMarchant, Vanessa
dc.contributor.authorRodrigues-Diez, Raul
dc.contributor.authorDolade, Nuria
dc.contributor.authorSuarez-Alvarez, Beatriz
dc.contributor.authorKerr, Bredford
dc.contributor.authorValdivielso, Jose M
dc.contributor.authorRuiz-Ortega, Marta
dc.contributor.authorRayego-Mateos, Sandra
dc.date.accessioned2019-06-28T17:31:48Z-
dc.date.available2019-06-28T17:31:48Z-
dc.date.issued2018
dc.identifier.citationMediators Inflamm..2018;(2018):2931049
dc.identifier.urihttps://hdl.handle.net/20.500.12530/34289-
dc.description.abstractThe growing incidence of obesity, hypertension, and diabetes, coupled with the aging of the population, is increasing the prevalence of renal diseases in our society. Chronic kidney disease (CKD) is characterized by persistent inflammation, fibrosis, and loss of renal function leading to end-stage renal disease. Nowadays, CKD treatment has limited effectiveness underscoring the importance of the development of innovative therapeutic options. Recent studies have identified how epigenetic modifications participate in the susceptibility to CKD and have explained how the environment interacts with the renal cell epigenome to contribute to renal damage. Epigenetic mechanisms regulate critical processes involved in gene regulation and downstream cellular responses. The most relevant epigenetic modifications that play a critical role in renal damage include DNA methylation, histone modifications, and changes in miRNA levels. Importantly, these epigenetic modifications are reversible and, therefore, a source of potential therapeutic targets. Here, we will explain how epigenetic mechanisms may regulate essential processes involved in renal pathology and highlight some possible epigenetic therapeutic strategies for CKD treatment.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAnimals
dc.subject.meshDNA Methylation
dc.subject.meshEpigenesis, Genetic
dc.subject.meshFibrosis
dc.subject.meshHistone Code
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshKidney
dc.subject.meshKidney Failure, Chronic
dc.subject.meshMicroRNAs
dc.subject.meshRenal Insufficiency, Chronic
dc.titleEpigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology.
dc.typeArtículo
dc.identifier.pubmedID30647531
dc.format.volume2018
dc.format.page2931049
dc.identifier.e-issn1466-1861
dc.identifier.journalMediators of inflammation
dc.identifier.doi10.1155/2018/2931049
dc.identifier.pmcPMC6311799
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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