Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/34381
Title: A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility.
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Issue Date: 2018
Citation: PLoS ONE.2018;(13)12:e0209343
Abstract: The TNFSF13B (TNF superfamily member 13b) gene encodes BAFF, a cytokine with a crucial role in the differentiation and activation of B cells. An insertion-deletion variant (GCTGT→A) of this gene, leading to increased levels of BAFF, has been recently implicated in the genetic predisposition to several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Based on the elevated levels of this cytokine found in patients with giant cell arteritis (GCA) and systemic sclerosis (SSc), we aimed to assess whether this functional variant also represents a novel genetic risk factor for these two disorders.
PMID: 30586461
URI: https://hdl.handle.net/20.500.12530/34381
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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