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|Title:||Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations.|
Cell Line, Tumor
Microfluidic Analytical Techniques
Gene Expression Regulation, Neoplastic
|Abstract:||Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic instability and eventually cell invasion. However, there is a lack of biomarkers to predict what patients will transition to a more invasive tumor or how DCIS cells manage to survive in this harsh microenvironment.|
|Appears in Collections:||Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos|
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