Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/35168
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dc.contributor.authorRodríguez-Galán, Ana
dc.contributor.authorFernández-Messina, Lola
dc.contributor.authorSánchez-Madrid, Francisco
dc.date.accessioned2019-06-28T17:48:20Z-
dc.date.available2019-06-28T17:48:20Z-
dc.date.issued2018
dc.identifier.citationFront Immunol.2018;(9):2148
dc.identifier.urihttps://hdl.handle.net/20.500.12530/35168-
dc.description.abstractMiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectCD4
dc.subjectCD8
dc.subjectT cell activation
dc.subjectT lymphocyte
dc.subjectimmunoregulatory molecules
dc.subjectmiRNA signature
dc.subjectmicroRNAs (miRNAs)
dc.titleControl of Immunoregulatory Molecules by miRNAs in T Cell Activation.
dc.typeArtículo
dc.identifier.pubmedID30319616
dc.format.volume9
dc.format.page2148
dc.identifier.e-issn1664-3224
dc.identifier.journalFrontiers in immunology
dc.identifier.doi10.3389/fimmu.2018.02148
dc.identifier.pmcPMC6167432
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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